The linear mixed model with an added integrated Ornstein-Uhlenbeck (IOU) process (linear mixed IOU model) allows for serial correlation and estimation of the degree of derivative tracking. It is rarely used, partly due to the lack of available software. We implemented the linear mixed IOU model in Stata and using simulations we assessed the feasibility of fitting the model by restricted maximum...

A formula for evaluation of the distribution of a linear combination of independent inverted gamma random variables by one-dimensional numerical integration is presented. The formula is direct application of the inversion formula given by Gil–Pelaez [4]. This method is applied to computation of the generalized p-values used for exact significance testing and interval estimation of the parameter...

SUMMARY New rank-based methods for analyzing data from multisite clinical trials are presented ·in the context of "mixed" linear models. In contrast to current rank methods, the new procedures test for a drug main effect in the presence of a random drug by site interaction (or drug by investigator interaction when there is only one investigator per site). Analogous procedures are also provided ...

The technical equipment developed and used in both installation and operation processes in refineries, oil and gas pipelines, and gas booster stations has always been expensive. Hence, managers at different organizational levels are keen to find methods to control and reduce these costs. Generally speaking, the operators in a gas booster station choose the operating devices without considering ...

Background: Breast cancer is one of the most common diseases in women and causes more deaths rather than other cancers. The increasing trend of breast cancer in Iran makes clear the need of extensive breast cancer research in this area. Some studies showed that in the variety countries and even in the different areas in one country has different risk of breast cancer incidence and this is a rea...

Two popular approaches for relating correlated measurements of a non-Gaussian response variable to a set of predictors are to fit a marginal model using generalized estimating equations and to fit a generalized linear mixed model by introducing latent random variables. The first approach is effective for parameter estimation, but leaves one without a formal model for the data with which to asse...

the aim of this study is to propose a new mixed integer linear programming (milp) model to find the minimum required number of yard cranes, rubber tyred gantry cranes (rtgcs), for completion the total amount of works at the end of planning horizon. in other word, we find the optimal number of yard cranes in a container terminal which completes the total amount of works. the paper supports the p...