MicroRNAs (miRNAs) regulate the expression of a large number of protein-coding genes. Their primary transcripts (pri-miRNAs) have to undergo multiple processing steps to reach the functional form. Little is known about how the processing of miRNAs is modulated. Here we show that the RNA-binding protein DiGeorge critical region-8 (DGCR8), which is essential for the first processing step, is a he...

more children ever.3 A study of births to ever-married women found that the proportion of births that were unplanned decreased from 38% in 1969–1973 to 32% in 1978–1982, then increased again to 35% in 1984–1988.4 Another study comparing the 1982 and 1988 NSFG survey results found that there had been no change in the unintended pregnancy rate between 1982 and 1987, but that the unintended birth ...

The goal of this study was to provide a reasonable assessment of how probe substrate selection may impact the results of in vitro aldehyde oxidase (AO) inhibition experiments. Here, we used a previously studied set of seven known AO inhibitors to probe the inhibition profile of a pharmacologically relevant substrate N-[(2dimethylamino)ethyl]acridine-4-carboxamide (DACA). DACA oxidation in human...

The goal of this study was to provide a reasonable assessment of how probe substrate selection may impact the results of in vitro aldehyde oxidase (AO) inhibition experiments. Here, we used a previously studied set of seven known AO inhibitors to probe the inhibition profile of a pharmacologically relevant substrate N-[(2dimethylamino)ethyl]acridine-4-carboxamide (DACA). DACA oxidation in human...

The global food system makes a significant contribution to climate changing greenhouse gas emissions with all stages in the supply chain, from agricultural production through processing, distribution, retailing, home food preparation and waste, playing a part. It also gives rise to other major environmental impacts, including biodiversity loss and water extraction and pollution. Policy makers a...

A 57-year-old man was referred to the hospital because of fever and jaundice. The patient had been in good health until four years earlier, when a noninvasive, papillary transitional-cell carcinoma of the bladder, grade 1 on a scale of 1 to 3, was excised. Similar tumors were excised 12 and 18 months later. One year before admission, live bacille Calmette–Guérin (BCG) microorganisms were admini...

Human Factors Integration Defence Technology Centre, Transportation Research Group, University of Southampton, School of Civil Engineering and the Environment, Highfield, Southampton, SO17 1BJ, UK; Human Factors Group, Monash University Accident Research Centre, Building 70, Clayton Campus, Monash University, Victoria 3800, Australia; School of Engineering and Design, Brunel University, Uxbridg...

Background: Stereoscopic assessment of the optic disc morphology is an important part of the care of patients with glaucoma. The aim of this study was to assess stereoviewing of stereoscopic optic disc images using an example of the new technology of autostereoscopic screens compared to the liquid shutter goggles. Methods: Independent assessment of glaucomatous disc characteristics and measurem...

Up until now, we have mainly studied how to decrease the query time, and the preprocessing time of our data structures. In this lecture, we will focus on maintaining the data as compactly as possible. Our goal will be to get as close the information theoretic optimum as possible. We will refer to this optimum as OPT. Note that most ”linear space” data structures we have seen are still far from ...