MicroRNAs (miRNA) are a class of short noncoding RNA that play important roles in controlling gene expression. Many miRNAs have been identified as being regulators bone cell function, thus affecting the remodeling processes. In addition to expressed specific tissues and exerting intracellular effects, can enter blood where they be taken up by other tissues. These circulating (c-miRNA) also clin...

Epilepsy is a common and serious neurological disorder characterised by recurrent spontaneous seizures. Frontline pharmacotherapy includes small-molecule antiseizure drugs that typically target ion channels neurotransmitter systems, but these fail in 30% of patients do not prevent either the development or progression epilepsy. An emerging therapeutic microRNA (miRNA), small noncoding RNAs nega...

Long non-coding RNAs (lncRNAs) play a multifaceted role in transcriptional regulation, and the potential molecular regulatory mechanisms of lncRNAs lncRNA–miRNA–mRNA networks body color formation are great significance for its selective breeding. Therefore, lncRNA-miRNA-mRNA ceRNA network red- black-colored Plectropomus leopardus were identified analyzed. Sequencing analyses 167 differentially ...

background esophageal, stomach, and colorectal cancers are commonly lethal gastrointestinal tract (git) neoplasms, causing almost two million deaths worldwide each year. some environmental risk factors are acknowledged; however, genetic defects can significantly contribute to predisposition to git cancers. accordingly, recent works have shown that single-nucleotide polymorphisms (snps) within m...

Abstract Introduction Ischaemia reperfusion injury (IRI) is an unavoidable, significant consequence of renal transplantation. MicroRNAs are small, non-coding RNA molecules that regulate multiple downstream mRNA targets. MiRNA-21-5p and miRNA-24-3p have been previously implicated in IRI. Antisense oligonucleotides (ASOs) block specific microRNAs, with previous work by our group demonstrating the...

Abstract Background Age-related sarcopenia meaningfully increases the risks of functional limitations and mortality in older adults. Although circulating microRNAs (c-miRNAs) are associated with aging-related cellular senescence inflammation, relationships between c-miRNAs adults remain unclear. This study investigates whether myo-miRNAs inflammation-related miRNAs Methods investigation recruit...