We investigated the effects of photoreceptor degeneration on the anatomy and physiology of inner retinal neurons in a mouse model of retinitis pigmentosa, the retinal degeneration (rd) mutant mouse. Although there is a general assumption that the inner retinal cells do not suffer from photoreceptor death, we confirmed major changes both accompanying and after this process. Changes include sprou...

This is a brief review of data obtained by analyzing the morphology and the physiology of the retinas in rd/rd and normal, wt mice, aged 10-90 days. Second-order neurons of the rd/rd show abnormalities that start with the anomalous development of rod bipolar cells around P10 and culminate with the atrophy of dendrites in cone bipolar cells, mostly evident at P90. Horizontal cells remodel consid...

To determine the effects of the recessive retinal degeneration (rd) gene on behavioral performance, three Alzheimer's transgenic lines (APPsw, P301L, APPsw + P301L) and non-transgenic littermates were evaluated in a comprehensive behavioral battery between 5 and 8.5 months of age. For all four genotypes collectively, rd homozygosity resulted in profound impairment in spatial cognitive tasks req...

This article describes the R package rdrobust, which provides data-driven graphical and inference procedures for RD designs. The package includes three main functions: rdrobust, rdbwselect and rdplot. The first function (rdrobust) implements conventional local-polynomial RD treatment effect point estimators and confidence intervals, as well as robust bias-corrected confidence intervals, for ave...

The "runt domain" (RD) is a 128 amino acid region of the Drosophila pair-rule gene runt. This highly conserved region delineates the DNA-binding domain of a new family of transcription factors; the RD proteins. The family includes genes from Drosophila, chicken and mammals that are involved in a wide range of developmental processes, from sex determination and neurogenesis in Drosophila to hema...

INTRODUCTION Radiation damping (RD) describes a second-order effect where the signal-induced current in the receiver coil acts back onto the primary spin system [1]. According to Lenz’s law, the RD field acts in a way to oppose its original cause. In that sense RD can be understood as a 1) self-generating and 2) selfregulating flip-back pulse, which causes the transverse magnetization to return...

In the absence of a randomized control trial, regression discontinuity (RD) designs can produce plausible estimates of the treatment effect on an outcome for individuals near a cutoff score. In the standard RD design, individuals with rating scores higher than some exogenously determined cutoff score are assigned to one treatment condition; those with rating scores below the cutoff score are as...

Abstract: Robust design (RD), implemented in statistical and mathematical procedures to simultaneously minimise the process bias and variability, is widely used in many areas of engineering and technology to represent complex real-world industrial settings. For RD modelling and optimisation, response surface methodology (RSM) is often utilised as an estimation method to represent the functional...