BACKGROUND This phase II CALGB trial evaluated the activity and safety of an extended induction schedule of galiximab (G) plus rituximab (R) in untreated follicular lymphoma (FL). PATIENTS AND METHODS Patients with previously untreated FL (grades 1, 2, 3a) received 4 weekly infusions of G + R, followed by an additional dose every 2 months four times. International Workshop Response Criteria w...

Burgundy is known both for its wines and its food products but they developed independently from each other. This paper examines the long march towards maximal wine quality which started before the beginning of the Christian era. In the Middle-Ages, the Cistercian monks brought up the notion of terroir which eventually led to the AOC system (Protected Designation of origin) in 1935. Burgundy is...

Diffuse large b-cell lymphoma (DLBCL) is an aggressive and potentially curable lymphoma that presents itself as stage I-II in 30% of all cases. It is known that in these localized stages, 15-20% of patients treated without rituximab eventually relapse, but less data exist regarding rituximab era. We have analyzed clinico-pathological features and risk of relapse in 98 patients with I-II stage D...

Introduction Cardiac excitation–contraction coupling is a transduction cascade that results in muscle contraction and relaxation. In ventricular myocytes, the arrival of an action potential activates sarcolemmal L-type Ca channels, and the subsequent inward Ca current, in turn, activates several RyRs in the SR membrane (the Ca release unit [CRU]). Activation of a CRU causes more Ca to be releas...

Ca(2+) sparks arise from the stochastic opening of spatially discrete clusters of ryanodine receptors called a Ca(2+) release unit (CRU). If the RyR clusters were not spatially separated, then Ca(2+) released from one RyR would immediately diffuse to its neighbor and lead to uncontrolled, runaway Ca(2+) release throughout the cell. While physical separation provides some isolation from neighbor...

Introduction Cardiac excitation–contraction coupling is a transduction cascade that results in muscle contraction and relaxation. In ventricular myocytes, the arrival of an action potential activates sarcolemmal L-type Ca channels, and the subsequent inward Ca current, in turn, activates several RyRs in the SR membrane (the Ca release unit [CRU]). Activation of a CRU causes more Ca to be releas...

Varying, limiting numbers of unseparated or purified cells (Ly-5.1). either from 14.5-day-old fetal liver (FL) or from adult bone marrow (BM) were coinjected with I O 5 unseparated BM cells (Ly-5.2) into lethally irradiated adult C57B1/6 recipients (Ly-5.2). The kinetics of donor cell repopulation of the lymphoid and myeloid compartments by Ly-5.1’ donor hematopoietic stem cells (ie, competitiv...

Introduction Cardiac excitation–contraction coupling is a transduction cascade that results in muscle contraction and relaxation. In ventricular myocytes, the arrival of an action potential activates sarcolemmal L-type Ca channels, and the subsequent inward Ca current, in turn, activates several RyRs in the SR membrane (the Ca release unit [CRU]). Activation of a CRU causes more Ca to be releas...

This report presents updated time-to-event variables from a multicenter phase II trial of reduced-dose 90Y ibritumomab tiuxetan in patients with relapsed or refractory low-grade, follicular, or transformed B-cell non-Hodgkin's lymphoma (NHL) and mild thrombocytopenia (platelet counts of 100 to 149 x 10(9) platelets/L). Patients received a single course of ibritumomab tiuxetan radioimmunotherapy...

Patients with mantle cell lymphoma (MCL) generally respond to first-line immunochemotherapy, but often show chemoresistance upon subsequent relapses, with poor outcome. Several studies of the immunomodulator, lenalidomide, have demonstrated its activity in MCL including the MCL-001 study in relapsed/refractory patients who had failed defined prior therapies of anthracyclines or mitoxantrone, cy...