PURPOSE The purpose is to investigate whether STI571, through platelet-derived growth factor receptor inhibition, enhances the therapeutic response to the chemotherapeutic drug epothilone B (EPO906) and, if so, to analyze the mechanism(s) underlying the effect. EXPERIMENTAL DESIGN SCID mice with s.c. human anaplastic thyroid carcinomas were treated with different doses of EPO906 alone or in c...

BACKGROUND Delivery and tracking of endomyocardial stem cells are limited by the inability to image transplanted cells noninvasively in the beating heart. We hypothesized that mesenchymal stem cells (MSCs) could be labeled with a iron fluorophore particle (IFP) to provide MRI contrast in vivo to assess immediate and long-term localization. METHODS AND RESULTS MSCs were isolated from swine. Sh...

Background and purpose Hypoxia, high interstitial fluid pressure (IFP) and immune effects have individually been shown to modulate radiotherapy (RT) response in cervical cancer. The aim of this study was to investigate the interplay between hypoxia or IFP and circulating neutrophil levels, and their combined effect on survival following RT. Material and methods A total of 287 FIGO stage IB to...

Foods imported into Australia are subject to laboratory testing for microbiological and chemical hazards under the Imported Food Program (IFP) for the purposes of protecting public health and safety. The program, operating under the Imported Food Control Act 1992, is jointly administered by the Australian Quarantine Inspection Service (AQIS) and the Australia New Zealand Food Authority (ANZFA)....

We study the relationship between least and inflationary fixed-point logic. By results of Gurevich and Shelah from 1986, it has been known that on finite structures both logics have the same expressive power. On infinite structures however, the question whether there is a formula in IFP not equivalent to any LFP-formula was still open. In this paper, we settle the question by showing that both ...

Interstitial ̄uid pressure (IFP) is one of the main obstacles for macromolecular agents uptake and distribution in solid tumors. It has been demonstrated to reduce e€ectiveness of different macromolecular agents used in in vivo anti-tumor therapies, which on the other hand showed very good anti-tumor properties in in vitro conditions [L.T. Baxter, R.K. Jain, Microvascular Research 37 (1989) 77±...

Prediction under Uncertainty on a Mature Field – Reservoir engineering studies involve a large number of parameters with great uncertainties. To ensure correct future production, a comparison of possible scenarios in managing related uncertainties is needed. Comparisons can be performed with more information than only a single mean case for each scenario. The Bayesian formalism is well Oil & Ga...

We define a new class of games, called backtracking games. Backtracking games are essentially parity games with an additional rule allowing players, under certain conditions, to return to an earlier position in the play and revise a choice. This new feature makes backtracking games more powerful than parity games. As a consequence, winning strategies become more complex objects and computationa...

Boneh and Venkatesan have proposed a polynomial time algorithm for recovering a ”hidden” element α ∈ IFp, where p is prime, from rather short strings of the most significant bits of the residue of αt modulo p for several randomly chosen t ∈ IFp. González Vasco and the first author have recently extended this result to subgroups of IFp of order at least p 1/3+ε for all p and to subgroups of orde...