BACKGROUND HIV associated neurocognitive disorders (HAND) continue to affect cognition and everyday functioning despite anti-retroviral treatment (ART). Previous studies focused on mechanisms related to monocyte/macrophage mediated inflammation. However, in the ART era, there is increasing evidence for the involvement of CD8+ T-cells in CNS pathogenesis. METHODS To investigate the relationshi...

Lung cancer is the major caused cancer death in Taiwan. However, the treatment of human lung cancer is still unsatisfactory. Cantharidin was isolated from blister beetle and have been used as a traditional Chinese medicine and it has been reported to have biological activity such as anticancer, antibiotic, antivirus and immune-regulated functions. However, there is no available information to s...

Brain tumors' treatment and prognosis depend to a large extent on their grades. Grading tumors follows a set of rules that refers to domain knowledge. Developing an automatic grading system requires explicit and formal representation of the domain. The NCI Thesaurus is the major ontological resource in the cancer domain. However, the description of brain tumors and grades in the NCI Thesaurus d...

Stellera chamaejasme L. has been widely used in the treatment of lung, liver and esophageal cancer in Chinese traditional medicine. In our previous study, we found that the extract of Stellera chamaejasme L. (ESC) inhibited the growth and induced the apoptosis of human lung cancer NCI-H157 cells. In the present study, we investigated the cellular effects of an ESC-2 extract isolated from ESC in...

BACKGROUND The regional impact of care at a National Cancer Institute Comprehensive Cancer Center (NCI-CCC) on adherence to National Comprehensive Cancer Network (NCCN) ovarian cancer treatment guidelines and survival is unclear. STUDY DESIGN We performed a retrospective population-based study of consecutive patients diagnosed with epithelial ovarian cancer between January 1, 1996 and Decembe...

In the present study, we examined the relationship between cell phenotype and cell survival of three human non-small cell lung carcinoma cell lines (A549, NCI-H596 and NCI-H520). Cells in exponential growth at various densities were incubated for 24 h at 37 degrees C in a 5% CO2 humidified atmosphere and then exposed to UV radiation for 1 min (256 nm, 40 W, source-to-target distance 100 cm). Af...

Understanding solvation interactions is a key problem for many industrial fields: from pharmaceutical to material sciences. From quantum mechanical viewpoint, two main difficulties arise: firstly, takes place through weak (hydrogen bonds, van der Waals interactions), which are inherently difficult describe. Secondly, properties dynamic in nature, means proper statistical averaging required repr...