Letetresgene autoleucel is a genetically engineered NY-ESO-1–specific TCR T-cell therapy being investigated in mSS patients whose tumours express the NY-ESO-1 antigen and who are HLA-A*02:01, HLA-A*02:05, or HLA-A*02:06 allele positive (NY+/HLA+). Our objective was to understand prevalence & clinical characteristics of NY+/HLA+ nationally representative population. This retrospective cohort stu...

Background: Miscarriage is a common phenomenon complicating more than half of pregnancies. Recurrent Pregnancy Loss (RPL) is defined as three or more pregnancies lost before the twentieth week of gestation. It is believed that abnormality in maternal immune reaction to fetus and sharing of HLA antigens might be associated with RPL. Objective: To investigate the effect of HLA-DRB1 sharing betwee...

Introduction Systemic Lupus Erythematosus (SLE) is a complex autoimmune and inflammatory disease. Many studies show HLA alleles can be associated with SLE. The aim of this study was to determine the association of HLA-DRB1 alleles with juvenile- onset in Iranian children. Materials and Methods At a case – control study, 31 children with systemic lupus erythematosus (case group) who referred to ...

Background: Human leukocyte antigens (HLAs) are found to be significant genetic factors concerning the susceptibility of an individual to certain diseases. Objective: To determine the association between variants of class I (A and B) and class II (DRB1) HLA alleles and chronic renal failure (CRF), compared with healthy controls, in Yemen. Methods: A case-control study in the Urology and Nephrol...

Background: Human leukocyte antigen (HLA) gene is a highly polymorphic region. HLA typing is required to match patients and donors for transplantation; therefore, development of HLA registries is necessary for finding HLA match donors. HLA system is highly informative, and numerous studies have been conducted on HLA allele distribution in different populations. Methods: In this study,...

Background: The strong association of Behcet’s disease with HLA-B5 antigen has been observed in several ethnic groups from Middle East to Far East. Objective: To evaluate the frequency and association of HLA-B5 and also likelihood ratio of involvement in Behcet’s disease in a group of Iranian patients. Patients and Methods: HLA-B5 antigen typing was performed by serologic method in 56 patients ...

aim : the aim of this study was to evaluate the likelihood ratio and frequency of dq2 and dq8 in iranian patients with celiac disease (cd). background : the hla dq2 and hla dq8 are the important mediators in the development of celiac disease. a few studies evaluated the frequency of hla dq2 and hla dq8 haplotypes among the iranian population with low sample size. patients and methods : in this ...

Unrelated haematopoietic stem cell transplantation (HSCT) has evolved from an experimental protocol to a potentially curative first-line treatment in variety of haematologic malignancies. The continuous refinement protocols and supportive care paired with ongoing achievements the technological field histocompatibility testing enabled this transformation. Without doubt, HLA matching is still for...

background: the study aimed to examine the association between human leukocyte antigen (hla) class ii allele frequencies and breast cancer in iranian women. methods: a total of 100 patients with pathologically proven breast cancer who referred to cancer institute were randomly selected and compared with a group of age matched healthy blood donors (n = 80). hla class ii alleles were determined b...