Rifamycins have proven efficacy in the treatment of persistent bacterial infections. However, the frequency with which bacteria develop resistance to rifamycin agents restricts their clinical use to antibiotic combination regimens. In a program directed toward the synthesis of rifamycins with a lower propensity to elicit resistance development, a series of compounds were prepared that covalentl...

Case-Based Reasoning (CBR) is a recognised and well established method for building medical systems. In this paper, we identify strengths and weaknesses of CBR in medicine. System properties, divided into construction-oriented and purpose-oriented, are used as the basis for a survey of recent publications and research projects. The survey is used to find current trends in present medical CBR re...

Case-based reasoning (CBR) aims at using experience from the past in order to guide future problem solving rather than “starting from scratch” every time. We propose a CBR strategy particularly suitable for realizing this principle if heuristic search is used as a problem solving method: Given a new problem, a CBR method exploits previously solved problems in order to predict a region of the se...

When we use Case-Based Reasoning (CBR) for practical applications, it is often the case to implement two kinds of problem solvers: casebased one and knowledge-based/conventional one. The complex integration of such plural reasoners often causes serious VV~T problems: performance of problem solving, quality of solutions, and so on. In this paper, we ~ldress the performance validation problems of...

A CBR system needs a good case retention strategy to decide which cases to incorporate into the case base in order to maximize the performance of the system. In this work we present a collaborative case retention strategy, designed for multiagent CBR systems, called the Collaborative Case Bargaining strategy. The CCB strategy is a bargaining mechanism in which each CBR agent tries to maximize t...

customers and customer-service personnel. He argued that CBR systems are easy to assess, develop, and deploy (for example, QUICKSOURCE was created in six months) and can be evaluated in terms of their cost benefits. Finally, John Lemmer (Rome Laboratories) outlined lessons learned through his experience in managing the funding for five groups researching CBR for crisis battle planning. He descr...

By design, Case-Based Reasoning (CBR) systems do not need deep general knowledge. In contrast to (rule-based) expert systems, CBR systems can already be used with just some initial knowledge. Further knowledge can then be added manually or learned over time. CBR systems are not addressing a special group of users. Expert systems, on the other hand, are intended to solve problems similar to huma...

The foundations of an area are concerned with the basic elements underlying the problems, methods, results and applications of the field. Sometimes this is easy to determine, e.g. when one is concerned with the foundations of logic. In CBR it is not as simple because CBR is in the intersection and the interest of different disciplines of a rather heterogeneous nature. Each discipline has its ow...

In this paper we present the results of the MIE/GMDS-2000 Workshop 'Case-Based Reasoning for Medical Knowledge-based Systems'. While in many domains Cased-Based Reasoning (CBR) has become a successful technique for knowledge-based systems, in the medical field attempts to apply the complete CBR cycle are rather exceptional. Some systems have recently been developed, which on the one hand use on...

An investigation is described into the application of quality function deployment (QFD) and case based reasoning (CBR) to software quality assessment. It is believed that the integration of CBR and QFD may be an effective means of supporting the development of quality software. The main aim in the research is to develop a CBR oriented software quality advisor to support the attainment of qualit...