OBJECTIVE The study investigated the effect of angiotensin receptor blockers (ARB) on glucose homeostasis and inflammatory parameters in patients with impaired glucose tolerance (IGT). RESEARCH DESIGN AND METHODS We prospectively studied the insulin sensitivity index (ISI) and homeostasis model assessment-insulin resistance (HOMA-IR) in 13 obese males with IGT and in 13 matched control subjec...

OBJECTIVES A national survey of diabetes and impaired glucose tolerance (IGT) conducted in 2000 AD in six major cities of India showed a high prevalence of diabetes (12.1%) and IGT (14%). Prevalence of IGT was higher than that of diabetes in subjects with less than 40 years when compared with older subjects. This analysis was done to look for differences in the risk factors associated with IGT ...

OBJECTIVE Daily physical activity remains an effective strategy to prevent obesity and type 2 diabetes. However, the metabolic response to exercise training is variable, and the precise clinical and molecular determinants that mark the metabolic improvements remain unknown. We tested the hypothesis that clinical improvements in glucose control after low-intensity exercise in individuals with im...

BACKGROUND The Iowa Gambling Task (IGT) has been recommended as an index of reward sensitivity, which is elevated in bipolar disorder. We conducted a meta-analysis of IGT performance in euthymic bipolar I disorder compared with control participants. Findings indicated that people with bipolar disorder make more risky choices than control participants, though the effect is small (g=0.35). It is ...

Risky decisions involve cognitive and emotional factors. As the primary test for the Somatic Marker Hypothesis (SMH), the Iowa Gambling Task (IGT) examines these factors. Skin conductance shows anticipatory physiological responses on the IGT supporting SMH. Pupil dilation offers an alternative physiological marker. Predictive effects of anticipatory pupillary responses to positive and negative ...

The Iowa Gambling Task (IGT) is sensitive to decision making impairments in several clinical groups with frontal impairment. However the complexity of the IGT, particularly in terms of its learning requirements, makes it difficult to know whether disadvantageous (risky) selections in this task reflect deliberate risk taking or a failure to recognise risk. To determine whether propensity for ris...

Abstract Impairments in decision-making have been suggested as a predisposing factor to obesity development. Individuals with excess weight display riskier decisions than normal people. Furthermore, adolescence is period of life which risky behavior may increase. We aimed investigate decision making applying the Outcome-Representation-Learning (ORL) model Iowa Gambling Task (IGT) adolescents we...

The Iowa Gambling Task (IGT) was developed as a test of Damasio’s Somatic Marker Hypothesis, which hypothesizes that emotion plays a role in decision-making. The IGT is now widely used to assess the role of emotion in decision-making in clinical populations. However, although Damasio’s experimental results using the IGT were consistent with the Somatic Marker Hypothesis, there is no direct evid...