CADTH recommends that Pluvicto should be reimbursed by public drug plans for the treatment of patients with metastatic castration-resistant prostate cancer (mCRPC) if certain conditions are met.
 only covered to treat prostate-specific membrane antigen (PSMA)-positive mCRPC who have received previous at least 1 androgen receptor pathway inhibitor (ARPI) and taxane-containing regimen...

The use of polymers as supports for enzyme immobilization is a strategy that enables to remove the enzymes from a chemical reaction and improve their efficiency in catalytic processes. In this work, cellulose triacetate (CTA) was used for physical adsorption of phospholipase Lecitase ultra (LU). CTA is more hydrophobic than cellulose, shows good performance in the lipases immobilization being a...

   Developing new bone pain palliation agents is a mandate in handling end-stage cancer patients around the world. Possibly, Lu-177 ethylenediaminetetramethylene phosphonic acid (177Lu-EDTMP) is a therapeutic agent which can be widely used in bone palliation therapy. In this study, 177Lu-EDTMP complex was prepared successfully using synthesized EDTMP ligand and 177LuCl3. Lu-177 chloride was obt...

UNLABELLED One mechanism of resistance to trastuzumab in human epidermal growth factor receptor-2 (HER2)-positive breast cancer (BC) is increased epidermal growth factor receptor (EGFR) expression. We have developed (111)In-labeled bispecific radioimmunoconjugates (bsRICs) that bind HER2 and EGFR on BC cells by linking trastuzumab Fab fragments through a polyethylene glycol (PEG24) spacer to ep...

In the present paper, by considering the notion of MV-modules which is the structure that naturally correspond to lu-modules over lu-rings, we prove some results on prime A-ideals and state some conditions to obtain a prime A-ideal in MV-modules. Also, we state some conditions that an A-ideal is not prime and investigate conditions that $Ksubseteq bigcup _{i=1}^{n}K_{i}$ implies $Ksubseteq K_{j...

The coordination properties of the ligand 2,2'-bipyrimidine-4,4'-dicarboxylic acid (H2bpd) with lanthanide(III) ions (Ln = Eu, Tb, or Lu) were investigated. syntheses H2bpd and its salts, [K2(bpd)(H2O)2] (1) [(AlkNH)Lu(bpd)2] (Alk Et, Hex, en), are described. In presence LnCl3 salts Lu, Tb), formation [Ln(bpd)2]- [Ln(bpd)(H2O)x]+ species was assessed by 1H nuclear magnetic resonance (NMR), spec...