نتایج جستجو برای: تاوان نرم l1
تعداد نتایج: 108009 فیلتر نتایج به سال:
PURPOSE Intrahepatic cholangiocarcinoma (ICC), a highly malignant hepatobiliary cancer, has a poor prognosis and is refractory to conventional therapies. The aim of this study is to discover a novel molecular target for the treatment of ICC. EXPERIMENTAL DESIGN To discover novel cancer-associated membrane antigens expressed in ICC cells, we generated monoclonal antibodies (mAb) by immunizing ...
The difference of PD-L1 expression between only HPV-positive patients and premalignant cervical lesion patients did not be reported in present studies. And to test the PD-L1 expression in some cervical cell lesion studies using cervical exfoliated cells sample also was ignored. Meanwhile, the PD-L1 expression as a predictive biomarker still existed controversy. So in the study, first to compare...
PD-L1 (CD274) contributes to functional exhaustion of T cells and limits immune responses in patients with cancer. In this study, we report the identification of an human leukocyte antigen (HLA)-A2-restricted epitope from PD-L1, and we describe natural, cytolytic T-cell reactivity against PD-L1 in the peripheral blood of patients with cancer and healthy individuals. Notably, PD-L1-specific T ce...
Huge efforts have been devoted to develop therapeutic monoclonal antibodies targeting human Programmed death-ligand 1 (hPD-L1) for treating various types of human cancers. However, thus far there is no suitable animal model for evaluating the anti-tumor efficacy of such antibodies against hPD-L1. Here we report the generation of a robust and effective system utilizing hPD-L1-expressing mouse tu...
BACKGROUND Recent clinical trial results have suggested that programmed cell death ligand 1 (PD-L1) expression measured by immunohistochemistry may predict response to anti-programmed cell death 1 (PD-1) therapy. Results on the association between PD-L1 expression and survival among patients with advanced non-small cell lung cancer (NSCLC) treated with chemotherapy are inconsistent. MATERIAL ...
Background DNA methylation of the immune checkpoint gene PD-L1 has recently been shown to be associated with PD-L1 mRNA expression in various malignancies. This study aimed to investigate the association of PD-L1 and PD-L2 methylation with mRNA expression, immune cell infitration, protein expression and human papilloma virus (HPV) infection in head and neck squamous cell carcinoma (HNSCC) patie...
طی سالیان اخیر کلم زینتی به‌دلیل داشتن اندامهای هوایی رنگی بادوام و مقاومت خوب به شرایط محیطی در فضای سبز بسیار استفاده می‌شود. بنابراین، ازدیاد درونشیشهای کلم زینتی در چند آزمایش مطالعه شد. غلظتهای مختلف بنزیل آدنین (mg/L1/0، 5/0 و 1)، 2,4-D (mg/L1/0، 5/0)، نیترات نقره (mg/L 2و4) و نوع رقم (بنفش و سفید) در مرحلۀ استقرار بهکار گرفته شد. همچنین تیمارهای مرحلۀ پرآوری شامل بنزیل آدنین (mg/L1/...
Abstract. The main aim of the paper is to study some quantitative aspects of the stability of the weak fixed point property for nonexpansive maps in l1 (shortly, w-fpp). We focus on two complementary approaches to this topic. First, given a predual X of l1 such that the σ(l1, X)-fpp holds, we precisely establish how far, with respect to the Banach-Mazur distance, we can move from X without losi...
Expression of the programmed death-1 (PD-1) ligand 1 (PD-L1) is used to select patients and analyze responses to anti-PD-1/L1 antibodies. The expression of PD-L1 is regulated in different ways, which leads to a different significance of its presence or absence. PD-L1 positivity may be a result of genetic events leading to constitutive PD-L1 expression on cancer cells or inducible PD-L1 expressi...
طی سالیان اخیر کلم زینتی به دلیل داشتن اندامهای هوایی رنگی بادوام و مقاومت خوب به شرایط محیطی در فضای سبز بسیار استفاده می شود. بنابراین، ازدیاد درون شیشه‌ای کلم زینتی در چند آزمایش مطالعه شد. غلظتهای مختلف بنزیل آدنین (mg/l1/0، 5/0 و 1)، 2,4-d (mg/l1/0، 5/0)، نیترات نقره (mg/l 2و4) و نوع رقم (بنفش و سفید) در مرحلۀ استقرار بهکار گرفته شد. همچنین تیمارهای مرحلۀ پرآوری شامل بنزیل آدنین (mg/l1/...
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