Let X1, X2, . . . , Xn be independent random variables and Sk = Pk i=1 Xi. We show that for any constants ak, P( max 1≤k≤n ||Sk| − ak| > 11t) ≤ 30 max 1≤k≤n P(||Sk| − ak| > t). We also discuss similar inequalities for sums of Hilbert and Banach space valued random vectors.

Adenosine (ADO) is an inhibitory neuromodulator that can increase nociceptive thresholds in response to noxious stimulation. Inhibition of the ADO-metabolizing enzyme adenosine kinase (AK) increases extracellular ADO concentrations at sites of tissue trauma and AK inhibitors may have therapeutic potential as analgesic and anti-inflammatory agents. ABT-702 is a novel and potent (IC(50) = 1. 7 nM...

Measurement of intracellular potassium activity (ak) is important in furthering our understanding of the basis of the low resting and maximum diastolic potentials and the membrane currents underlying pacemaker activity in the sinoatrial node. K-selective microelectrodes have been successfully applied to measure ak in Purkinje fibers, ventricular muscle, and atrium. Similar measurements in the s...

design of additional anti-LSC agents. Most interestingly, these compounds have been identified using a gene-expression signature derived from primitive AML CD34 ϩ cells to search through a broad spectrum of expression data obtained from several treatments performed on different nonhematopoi-etic cell types. This raises 2 important points. First, there may be no need to look at specific cancer s...

B-splines of order k can be viewed as a mapping N taking (k+1)-tuple increasing real numbers a0<⋯<ak and giving result certain piecewise polynomial function. Looking at this whole, basic properties B-spline functions imply that it has the following algebraic properties: (1) N(a0,…,ak) local support contained in interval [a0,ak]; (2) allows refinement, i.e. for every a∈∪j=0k−1(aj,aj+1) we have i...

Activated killer (AK) cells cytotoxic for freshly prepared autologous melanoma cells were generated in vitro when recombinant interleukin 2 (rIL2) was incubated with peripheral blood mononuclear cells from 11 of 12 patients with metastatic melanoma. The cytotoxic response first appeared significant after 3 days of culture with rIL2; it peaked after 6 days and then declined after 9 days of incub...

Site-directed mutagenesis in vitro was used to introduce stop codons in the genomic DNA of the alpha and beta chains of the murine class II major histocompatibility complex antigen, I-Ak. Mutated DNA was transfected into B lymphoma cells that were then selected by neomycin resistance and for their ability to express I-Ak molecules on their plasma membrane. The translational diffusion coefficien...

We examined the structural characteristics of a peptide Ag that determine its ability to interact with class II-MHC molecules and TCR. The studies reported here focused on recognition of the hen egg white lysozyme (HEL) tryptic fragment HEL(34-45) by two I-Ak-restricted T cell hybridomas. HEL(34-45) bound to I-Ak created more than one antigenic specificity. Experiments with truncated peptides a...