Tumor cells in hypoxic areas of solid tumors are resistant to conventional chemotherapy and radiotherapy and thus are obstacles of cancer therapy. We report here the feasibility of applying hypoxia-regulated expression of diphtheria toxin A (DT-A) for killing hypoxic tumor cells. The expression vector was constructed to express DT-A fused with hypoxia-inducible factor-1A (HIF-1A) oxygen-depende...

To investigate the relationship between dental caries and the salivary flow rate, secretory immunoglobulin A (sIgA) or other components in children, nonstimulated whole saliva was collected and teeth status was examined in 138 boys and 134 girls aged 11-12 years. The subjects were apparently healthy. The mean salivary flow rate was faster in boys than in girls (0.29 vs 0.18 ml/min, p < 0.001). ...

We have previously demonstrated that DT-010, a novel conjugate of danshensu (DSS) and tetramethylpyrazine (TMP), displays anti-tumor effects in breast cancer cells both in vitro and in vivo. In the present study, we investigated whether DT-010 enhances the chemotherapeutic effect of doxorubicin (Dox) in MCF-7 breast cancer cells and exerts concurrent cardioprotective benefit at the same time. O...

Arrays of octameric peptide libraries on cellulose paper were screened by using (32)P-autophosphorylated cGMP-dependent protein kinase Ialpha (cGPK) to identify peptide sequences with high binding affinity for cGPK. Iterative deconvolution of every amino acid position in the peptides identified the sequence LRK(5)H (W45) as having the highest binding affinity. Binding of W45 to cGPK resulted in...

There is disagreement among researchers about whether IQ tests or divergent thinking (DT) tests are better predictors of creative achievement. Resolving this dispute is complicated by the fact that some research has shown a relationship between IQ and DT test scores (e.g., Runco & Albert, 1986; Wallach, 1970). The present study conducted meta-analyses of the relationships between creative achie...

Several functional imaging studies have demonstrated the importance of fronto-parietal network in dual-task management. However, neural correlates underlying the difference in intensity of dual-task interference between the same and different response modalities remain unknown. Therefore, we investigated the relationship between brain activity associated with dual-task management and the combin...

let $a = (a_{i,j})_{1 leq i,j leq n}$ be an $n times n$ matrixwhere $n geq 2$. let $dt(a)$, its second immanant be the immanant corresponding to the partition $lambda_2 = 2,1^{n-2}$. let $g$ be a connected graph with blocks $b_1, b_2, ldots b_p$ and with$q$-exponential distance matrix $ed_g$. we given an explicitformula for $dt(ed_g)$ which shows that $dt(ed_g)$ is independent of the manner in ...