The interaction of human adenovirus (HAdV)-C5 and many other adenoviruses with blood coagulation factors (e.g., human factor X, FX) involves the binding of their GLA domain to the hexon capsomers, resulting in high levels of hepatotropism and potential hepatotoxicity. In this study, we tested the possibility of preventing these undesirable effects by using a GLA-mimicking peptide as a competito...

Human adenovirus serotype 5 (HAdV5)-based vectors administered intravenously accumulate in the liver as the result of their direct binding to blood coagulation factor X (FX) and subsequent interaction of the FX-HAdV5 complex with heparan sulfate proteoglycan (HSPG) at the surface of liver cells. Intriguingly, the serotype 35 fiber-pseudotyped vector HAdV5F35 has liver transduction efficiencies ...

血友病インヒビター患者の止血管理にバイパス止血剤が併用されるが確立された療法はない．今回，活性化第VII/第X因子（FVIIa/FX）および高用量組換え（r）FVIIaの併用療法を施行した血友病Bインヒビター患者1例の凝固能を評価した．止血困難な出血時にFVIIa/FX，高用量rFVIIaの順で投与したところ，FVIIa/FXまたは高用量rFVIIaの投与前後でAPTTは短縮し，トロンビン産生およびFVII抗原量は増加した．一方，FX抗原量はFVIIa/FXの投与前後でのみ増加した．また，高用量rFVIIa単独投与に比して，FVIIa/FX投与翌日の高用量rFVIIa追加投与後の凝固能は強まった．併用療法に際して過凝固の徴候は見られなかった．FVIIa/FX投与による高濃度FX存在下でのrFVIIa追加投与は，血友病Bインヒビターの難治性出血に対する合理的な止血戦略となり得る可能性が...

The increase in life expectancy, according to the World Health Organization, is a fact, and with it rises incidence of age-related neurodegenerative diseases. most recurrent symptoms are those associated tremors resulting from Parkinson’s disease (PD) or essential (ETs). main alternatives for treatment these patients medication surgical intervention, which sometimes have restrictions side effec...

and Applied Analysis 3 Definition 1.10 see 5 . Let X,G be a G-metric space and f, g : X → X be given mappings. We say that f is a generalized weakly G-contraction mapping of type B with respect to g if for all x, y, z ∈ X, the following inequality holds: ψ ( G ( fx, fy, fz )) ≤ ψ ( G ( gx, gx, fy ) G ( gy, gy, fz ) G ( gz, gz, fx ) 3 ) − φGgx, gx, fy, Ggy, gy, fz, Ggz, gz, fx, 1.2

BACKGROUND Hemodialysis (HD) patients with bone fractures have an increased risk for death. However, the risks for mortality and atherosclerotic complications in incident HD patients subsequently with bone fractures are unknown. METHODS Data derived from the Taiwan National Health Institute Research Database between January 1997 and December 2008 was analyzed. The enrolled patients included 3...

We present a very tedious proof of the n = 4 case of the Tied Dice Theorem. Suppose X = (x1; x2; x3; x4); Y = (y1; y2; y3; y4) 2 D(4; a; b; s) are distinct, tied, non-balanced dice. Let denote the number of pairs (i; j) with xi = yj ; as X and Y are tied, there must be (16 )=2 pairs (xi; yj) with xi > yj , and (16 )=2 pairs (xi; yj) with xi < yj . For each value of we list the various possible ...