REGULATION OF THE SUBCELLULAR LOCALIZATION OF THE G-PROTEIN SUBUNIT REGULATOR GPSM3 THROUGH DIRECT ASSOCIATION WITH 14-3-3 Patrick M. Giguère, Geneviève Laroche, Emily A. Oestreich, Joseph A. Duncan and David P. Siderovski* Department of Pharmacology and Division of Infectious Diseases, The University of North Carolina School of Medicine, Chapel Hill, North Carolina, 27599-7365; Department of P...

2012;25(2) S Afr J Clin Nutr Motswagole BS, Senior Nutritionist, Centre of Excellence for Nutrition, North West University (Potchefstroom) Kruger HS, Professor of Nutrition, Centre of Excellence for Nutrition, North West University (Potchefstroom) Faber M, Senior Specialist Scientist, Nutritional Intervention Research Unit, Medical Research Council Monyeki KD, Specialist Scientist, Chronic Dise...

The aim of this project was to produce guidance for a rationalised virological electron microscopy specimen testing policy for PHLS North West, to facilitate centralisation of a groupwide diagnostic electron microscopy service on a single site. Careful specimen selection to limit numbers and the groupwide use of commercially available enzyme immunoassays has allowed PHLS North West to reduce th...

A cluster of cases of familial amyloid polyneuropathy has been described in Donegal, north west Ireland. Two patients from this region have been shown to have the ala 60 mutation in the transthyretin gene. Three kindreds with this mutation have also been described in the United States. Genealogical and haplotype studies indicate that all known patients with this mutation are related and are des...

A Porroche-Escudero,* J Popay, B Barr, S Mosedale, A Ring, G Sadler, G Simpson, P Wheeler. National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care (NIHR CLAHRC) North West Coast, UK/ Division of Health Research, Lancaster University, UK; National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care (NIHR C...

A Novel DNA Repair Disorder With Thrombocytopenia, Nephrosis, and Features Overlapping Cockayne Syndrome Elizabeth Forsythe, Ruth Wild, Gabrielle Sellick, Richard S. Houlston, Alan R. Lehmann, and Emma Wakeling* Kennedy Galton Centre, North West Thames Regional Genetics Service, The North West London Hospitals NHS Trust, Middlesex, United Kingdom Section of Cancer Genetics, Institute of Cancer ...

The characteristics of life-long persistent infection of hepatitis B virus (HBV) and the prevalence of different genotypes of HBV in China may cause new recombinants. In north-west China, HBV inter-genotype recombinants have been reported frequently over the last decade. Here, we report a B/C inter-genotype recombinant HBV with a novel genome mosaic structure from Lanzhou, a city in north-west ...

In the classical Projection-based Model for cardinal directions [6], a two-dimensional Euclidean space relative to an arbitrary single-piece region, a, is partitioned into the following nine tiles: North-West, NW(a); North, N(a); North-East, NE(a); West, W(a); Neutral Zone, O(a);East, E(a); South-West, SW(a); South, S(a); and South-East,SE(a). In our Horizontal and Vertical Constraints Model [9...

Based on a systematic review of the scientific literature, the North West Oxygen Group have developed guidelines for oxygen therapy for patients who present with acute breathlessness. The above emergency medicine physicians, chest physicians and intensive care physicians have gained approval from their regional societies to have this document accepted as the agreed regional guidelines for the u...

The aim of this project was to produce guidance for a rationalised virological electron microscopy specimen testing policy for PHLS North West, to facilitate centralisation of a groupwide diagnostic electron microscopy service on a single site. Careful specimen selection to limit numbers and the groupwide use of commercially available enzyme immunoassays has allowed PHLS North West to reduce th...