Electromembrane extraction (EME) of the polar zwitterionic drugs, anthracyclines (ANT, doxorubicin, daunorubicin and its metabolite daunorubicinol), from rabbit plasma was investigated. The optimized EME compared to conventional sample pretreatment techniques such as protein precipitation (PP) liquid-liquid (LLE), mainly in terms reliability, recovery matrix effect. In addition, phospholipids p...