this paper describes 3d-qsar analysis and biological evaluation of 1,5-benzodiazepine analogues. benzodiazepine nucleus with its simple structure gives a good opportunity for further modification regarding an increase of its antimicrobial activity. we synthesized a series of benzodiazepine analogues from condensation of various chalcones and halo substituted o-phenelynene diamines. all compound...

introduction people have been trying to have a good life from many centuries ago. but always main problem is that what is the ideal life? in this direction various definitions and subjective and objective indicators about the quality of life are proposed and there are many problems to and acceptable universal definition in order to recognize the suitable indicators and its measuring. we should ...

objective(s): to explore the correlation between expression patterns and functions of mir-383 and ldha in hepatocellular cancer (hcc). materials and methods: we detected the expression of mir-383 and ldha in 30 hcc tissues and their matched adjacent normal tissues using qrt-pcr. then we performed mtt assay, foci formation assay, transwell migration assay, glucose uptake assay and lactate produc...

objective: osteon has been introduced as a bone substitute material. it is biphasic calcium phosphate (bcp) that use in dentistry. the aim of the present study was to evaluate the effect of osteon on the proliferation, cell viability and differentiation of saos-2 cells in vitro. also it was compared with cerasorb bone graft. materials and methods: two different bone grafts materials, osteon an...

in order to determine the lipids and lipoproteins profiles in iranian khouzestanian arab horses, blood samples were collected from the jugular vein of 77 horses(47 female, 30 male) from different age groups(< 6, 7-12, 12-36, 37-60, 61- 69 and > 96 months). serum cholesterol and triglyceride were measured by enzymatic methods and lipoproteins by precipitation methods. the results were analyzed b...

helicobacter pylori is related to iron deficiency anemia (ida) and inflammatory responses causing gastric and duodenal ulcer and carcinoma. moreover, it leads to deficiency of factors associated with iron adsorption and transfer. in the present study, we recruited 100 children (50 infected with h. pylori and 50 controls) aged 3-14 years old (40% male and 60% female) to evaluate the effect of h....

conclusions the current study highlights that the high level of resistance to many antibacterial agents and a gradual increase in the degree of per, oxa-10, shv and tem esbls among the majority of imipenem resistant p. aeruginosa isolated from patients with burn infection is an enormous threat in burn centers in iran. results the results showed that the majority of isolates (88%) were multi-dru...

the ability to maintain and study human tissues in in-vivo environment has proved to be a valuable tool in breast cancer research for several decades. the most widely tissues have been xenografts established human breast cancer cell lines into athymic nude mice. the aim of this study was to provide a new accurate and affordable method for the establishment of breast cancer xenograftin nude mice...

surface oxidized carbon vulcane xc-72 is prepared as catalyst support and platinumnanoparticles are chemically anchored onto the modified surface. the nanoparticles of pt weresynthesized by reduction of h2ptcl6 with sodium borohydride in a 5.5 m buffer solution ofsodium citrate; the complexation of citrate with metal ions is beneficial to the formation ofnanoparticles. the electro-oxidation of ...

to study the effects of drought stress and foliar application with salicylic acid on yield andit’s components and percentage of essential oil of nigella sativa l., a field experiment was conducted as split plot based on randomized complete block design with three replications at research farm of shahid bahonar university of kerman during growing season of 2013- 2014. the main factor was drought...