IN RECENT YEARS evidence has emerged that the Na-K-ATPase, a canonical active ion pump, has parallel roles as a platform for cell signaling. Na-K-ATPase has been shown to associate directly with other proteins in signaling complexes in cardiac myocytes, renal cells, and several other cell types (4). Signals transmitted through the Na-K-ATPase and associated Src have been implicated in hypertrop...

Previous studies showed that in rats with obstruction of the bile ducts draining the median and left hepatic lobes, and in rats with normal bile ducts in which the bile acid pool size and secretion were augmented by 48-h intraduodenal infusion of taurocholate, bile acid flux through secreting hepatocytes was increased. Under these conditions, taurocholate transport maximum exhibited a time-depe...

Cerebral ischemia-reperfusion injury (CIRI) is one of the main diseases leading to death and disability. Studying role mechanism drugs in mitigating CIRI great significance. In present study, effect formononetin from Trifolium pratense L. on oxidative stress, energy metabolism impairment inflammatory response after cerebral mice were investigated. Formononetin was extracted purified. The treate...

Microbial enzymes produced using biological processes are of great importance due to their contribution sustainable solutions for agricultural production. In our previous study, the chitinase enzyme from Lactobacillus coryniformis was purified, immobilized zinc oxide (ZnO) nanoparticles, and its effectiveness as a bioinsecticide against storage pest Sitophilus zeamais Motschulsky, 1855 (Coleopt...

AIMS Human atrial electrophysiology exhibits high inter-subject variability in both sinus rhythm (SR) and chronic atrial fibrillation (cAF) patients. Variability is however rarely investigated in experimental and theoretical electrophysiological studies, thus hampering the understanding of its underlying causes but also its implications in explaining differences in the response to disease and t...

Exposure to acidic and alkaline pHs results in an ionic imbalance. Cellular responses involved osmoregulation silver catfish exposed different (5.5, 7.5, 9.0) for 24 h were evaluated. The gills kidney collected measure Na+/K+-ATPase (NKA) H+-ATPase (V-ATPase) activities evaluate the expression of ion transporter-related genes: NKA (atp1a1), H+-ATPases (atp6v0a1b, atp6v0a2a, atp6v0a2b), Na+/H+ a...