نتایج جستجو برای: آنتی tumor necrosis factor tnf

تعداد نتایج: 1254222  

Journal: :Blood 1994
L M Minasian T P Szatrowski M Rosenblum T Steffens M E Morrison P B Chapman L Williams C F Nathan A N Houghton

Hemorrhagic tumor necrosis is an inflammatory event that leads to selective destruction of malignant tissues, with both potentially toxic and beneficial consequences. A pilot clinical trial was undertaken combining tumor necrosis factor-alpha (TNF-alpha) with the monoclonal antibody R24 (MoAb R24) against GD3 ganglioside in patients with metastatic melanoma. Patients received MoAb R24 to recrui...

Journal: :Molecular cell 2007
You-Sun Kim Michael J Morgan Swati Choksi Zheng-Gang Liu

Tumor necrosis factor (TNF) is an important cytokine in immunity and inflammation and induces many cellular responses, including apoptosis and necrosis. TNF signaling enables the generation of superoxide in phagocytic and vascular cells through the activation of the NADPH oxidase Nox2/gp91. Here we show that TNF also activates the Nox1 NADPH oxidase in mouse fibroblasts when cells undergo necro...

Journal: :Arthritis Research & Therapy 2005
Ranjeny Thomas

APC = antigen presenting cell; cTEC = thymic cortical epithelial cell; DC = dendritic cell; IκB = inhibitory κB; IL = interleukin; mTEC = medullary thymic epithelial cell; NFκB = nuclear factor κB; NIK = NFκB inhibitory kinase; NOD = non-obese diabetic; NZB = New Zealand black; TLR = tolllike receptor; TNF = tumor necrosis factor; TRAF6 = TNF receptor associated factor 6. Arthritis Research & T...

Journal: :middle east journal of digestive diseases 0
hadi emamat maryam noori forough foroughi marjan rismanchi hassan eini–zinab azita hekmatdoost

background: there is no convenient cheap pragmatic experimental model for nonalcoholic fatty liver disease (nafld)/nonalcoholic steatohepatitis (nash). we aimed to create a pragmatic model of nafld/nash. methods: sprague-dawley rats were fed a high-fat, high sugar homemade diet ad libitum for seven weeks. the high-fat, high sugar diet included 59% of energy derived from fat, 30% from carbohydra...

Abbas Shakoori Garakani Ghodratolah Panahi Habib Sadeghi Rad, Mohammad reza Noori daloii, Saman Mehrabi

Head and neck squamous cell carcinoma (HNSCC) represents a large majority of cancers arising from the head and neck, especially the oral cavity. Despite advances in therapy, the five-year survival rate remains low due to the number of patients presenting advanced stages of the disease. The role of epithelial-mesenchymal transition (EMT) in tumorigenesis in HNSCC remains unexplored. The current ...

Journal: :Bali Medical Journal 2022

Abstract Background: Breast cancer is the most common in women. The occurrence of metastasis breast should be detected early. Tumor necrosis factor-α (TNF-α) involved every step carcinogenesis process. A rise TNF-α level linked to advancement cancer. We aimed determine association between levels and metastases. Methods: An analytic cross-sectional study was conducted on women with treated at On...

Dabaghi Ghaleh, Talaate, Foroghi, Farshad , Javadi, Amir , Sahmani, Mehdi, Taherkhani, Khadijeh , Yargholi, Maryam ,

Background: Tumor Necrosis Factor Alpha (TNF-α) gene, as an inflammatory factor, plays an important role in reproductive physiology, especially in women with Polycystic Ovary Syndrome (PCOS). Objective: This study aims to investigate the relationship between the -1031 T/C polymorphism of TNF-α gene and biochemical factors in women with PCOS. Methods: In this case-control study, participants w...

Journal: :Clinical and experimental rheumatology 2004
M D Magnano W H Robinson M C Genovese

The development of tumor necrosis factor alpha (TNFalpha) inhibitor therapy is arguably the most significant achievement in the treatment of rheumatic diseases to date. One serious potential side effect associated with these agents is the onset of neurologic signs and symptoms. In this paper we will examine the relationship of TNFalpha antagonism and demyelinating disease. Reviewing early labor...

Journal: :The Journal of rheumatology. Supplement 2010
Edward C Keystone Carl F Ware

Tumor necrosis factor (TNF) plays a crucial role in the pathogenesis of immune-mediated inflammatory diseases (IMID). As a result, the inhibition of TNF is an important therapeutic avenue in the treatment of these pathophysiologically diverse disease states. This section discusses TNF, its receptors, and its role in immunoregulation and inflammation, as well as the currently available anti-TNF-...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید