OBJECTIVES The objective of this study was to investigate the effects of pentoxifylline (PTX), a drug that is mainly used for indications related to tissue hypoxia, on hypoxia-induced inhibition of skeletal muscle contractility and neuromuscular transmission in mice. We hypothesized that chronic PTX treatment alters skeletal muscle contractility and hypoxia-induced dysfunction. MATERIALS AND ...

Paclitaxel (PTX, taxol), a classical antitumor drug against a wide range of tumors, shows poor oral bioavailability. In order to improve the oral bioavailability of PTX, glycyrrhizic acid (GA) was used as the carrier in this study. This was the first report on the preparation, characterization and the pharmacokinetic study in rats of PTX-loaded GA micelles The PTX-loaded micelles, prepared with...

INTRAPLEURAL MINOCYCLINE FOR SPONTANEOUS PTX? Current initial treatment for primary spontaneous pneumothorax (PTx) has a substantial rate of recurrence. In this study (Lancet 2013;381:1277–82), investigators randomly assigned patients with a first episode of PTx to receive minocycline pleurodesis or simple aspiration and drainage. At 1 year, 29.2% patients in the minocycline group had a recurre...

Paclitaxel (PTX), introduced into the clinic in 1991, has revealed itself as an effective antimicrotubule drug for treatment of a range of otherwise intractable cancers. Along with docetaxel (DTX) and in combination with other agents such as cisplatin, it has proven to be a first-line therapy. Unfortunately, PTX and DTX carry severe liabilities such as debilitating side effects, rapid onset of ...

Introduction Cardiovascular mortality is significantly higher in patients with primary hyperparathyroidism (PHPT) compared to the general population. The role of renin-angiotensin-aldosterone system (RAAS) as a mediator cardiovascular pathology PHPT unclear, question whether successful parathyroidectomy (PTX) mitigates hypertension (HT), and left-ventricular (LV) dysfunction. Methods In 45 cons...

Introduction: Chronic kidney disease (CKD) may increase morbidity and mortality. Therefore, early detection of inflammation in transplant recipients with a high risk rejection is important. Objectives: This study was conducted to compare serum levels pentraxin-3 (PTX-3), mannose binding lectin (MBL) sensitivity C-reactive protein (hs-CRP) patients chronic renal failure before after transplantat...

The plasmalemmal Na(+)-K(+)-ATPase (NKA) pump is the receptor for the potent marine toxin palytoxin (PTX). PTX binds to the NKA and converts the pump into a monovalent cation channel that exhibits a slight permeability to Ca(2+). However, the ability of PTX to directly increase cytosolic free Ca(2+) concentration ([Ca(2+)](i)) via Na(+) pump channels and to initiate Ca(2+) overload-induced onco...

In this study, it was aimed to develop a nano drug system that can be used in passive targeting pancreatic cancer treatment. Hydroxyapatite nanocrystals (n-HAP) produced by hydrothermal process and graphene oxide (GO) hummers method were increase the carrier capacity of activate release kinetics loading capacity. Analyses performed for nanocomposite systems; FT-IR, XRD, TGA, BET analysis, Zeta ...

PTX (Paclitaxel) is an antimitotic agent used in the treatment of a number of major solid tumours, particularly in breast and ovarian cancer. This study was undertaken to gain insight into the molecular alterations producing PTX resistance in ovarian cancer. PTX treatment is able to induce apoptosis in the human ovarian carcinoma cell line, CABA I. PTX-induced apoptosis in CABA I cells was acco...

AIM The graphene oxide (GO) sheet has been considered one of the most promising carbon derivatives in the field of material science for the past few years and has shown excellent tumor-targeting ability, biocompatibility and low toxicity. We have endeavored to conjugate paclitaxel (PTX) to GO molecule and investigate its anticancer efficacy. MATERIALS & METHODS We conjugated the anticancer dr...