Introduction: Recognition of human leukocyte antigens (HLA) is of importance for hematopoietic stem cell transplantation. Any HLA-mismatches between the donor and recipient can cause graft rejection or other complications. In HLA-typing experiments, usage of HLA-known reference cells accompany with HLA-unknown samples is obligatory. Some international centers represent these cells with high e...

Objective: This study aimed to investigate the association between HLA alleles and visceral leishmaniasis (VL) in a sample of Iraqi patients. Methods: A total of 30 patients were studied, in addition to 20 age, gender and ethnicity matched controls. All subjects were genotyped by polymerase chain reaction-sequence specific primers (PCR-SSP) method. Results: For HLA-class I region (A and B loci)...

Background: Non-Hodgkin lymphoma (NHL) includes a wide range of diseases with different clinical and biological features. NHL is usually presented as localized or generalized lymphadenopathy. It has been suggested that the HLA class I and II are associated with susceptibility to NHL. Different ethnic groups have been found to have different HLA class I and II alleles which affect NHL. Objective...

The association of HLA and disease varies in different populations. We have . studied the association of HLA class I in Iranian psoriatic patients, in order to compare this association with other reports. Fifty-one Iranian patients with psoriasis were HLA typed. The frequency of HLA antigens in patients and patient subgroups, based on clinical patterns, age of onset, family history and prov...

Background: Human leukocyte antigen (HLA) class II has shown potential in determining prognosis, understanding medication reactions, and predicting onset of Graves’ disease. The aim this study is to further investigate the association between disease HLA II, specifically HLA-DQ HLA-DR, via meta-analysis find HLAs that can be examined for prognostic reasons.

Gene variants derived from Neanderthals or Denisovans can be associated with polygenic traits, validating the utility of notion about archaic gene flow. Endoplasmic reticulum aminopeptidase 1 (ERAP1) haplotypes control disease risk primarily mediated by HLA-C*06:02, HLA-B*27 and HLA-B*51 for psoriasis, ankylosing spondylitis (AS) Behçet's (BD). In this genetic interaction corresponds to differe...

Abstract Sensitization to nickel (Ni2+) is the most common T cell mediated type IV hypersensitivity, although mechanisms by which Ni2+ alters antigen presentation are not understood. To study how TCR then recognizes bound MHC molecule, we performed paired single RNA sequencing of PBMCs from two highly sensitized subjects orthopedic implants and characterized three specific CD4+ clones. One rest...