BERNARDO M. ÁBREGO, SILVIA FERNÁNDEZ-MERCHANT, AND BERNARDO LLANO Abstract. Given integers k ≥ 1 and n ≥ 0, there is a unique way of writing n as n = ¡nk k ¢ + ¡ nk−1 k−1 ¢ + ... + ¡ n1 1 ¢ so that 0 ≤ n1 < · · · < nk−1 < nk. Using this representation, the KruskalMacaulay function of n is defined as mk (n) = ¡ nk−1 k−1 ¢ + ¡ nk−1−1 k−2 ¢ + ... + ¡ n1−1 0 ¢ . We show that if a ≥ 0 and a < mk+1 (...

Redox potentials of a menaquinone (MK-6), isolated in earlier researches from two species of the obligately anaerobic genus, Desulfovibrio, as well as two other vitamins K(2)-menaquinones (MK-5) and (MK-9)- have been determined polarographically. The measurements have been validated by determination of redox potentials of 1,4-naphthoquinone and vitamin K(1) which agree with published potentiome...

MK-2206 is an inhibitor of Akt activation. It has been investigated as an anticancer drug in clinical trials assessing the potential of pAkt targeting therapy. The purpose of this study was to identify conditions that increase the sensitivity of cancer cells to MK-2206. We found that the treatment of cancer cells with a high concentration of salinomycin (Sal) reduced total Akt protein levels bu...

Midkine (MK), a heparin-binding growth factor, can regulate cell growth, survival and differentiation. MK is expressed at high levels in a variety of human carcinomas. Recently, the urine and serum MK concentration was analyzed in gastric cancer patient. However, the association of the cytokine mRNA expression with the categorical clinicopathological variables of the tumors and the location of ...

PURPOSE Wee1 regulates key DNA damage checkpoints, and in this study, the efficacy of the Wee1 inhibitor MK-1775 was evaluated in glioblastoma multiforme (GBM) xenograft models alone and in combination with radiation and/or temozolomide. EXPERIMENTAL DESIGN In vitro MK-1775 efficacy alone and in combination with temozolomide, and the impact on DNA damage, was analyzed by Western blotting and ...

The heparin binding molecules MK and HB-GAM are involved in the regulation of growth and differentiation of many tissues and organs. Here we analyzed the expression of MK and HB-GAM in the developing mouse incisors, which are continuously growing organs with a stem cell compartment. Overlapping but distinct expression patterns for MK and HB-GAM were observed during all stages of incisor develop...

Cardiac remodeling is thought to be the major cause of chronic heart dysfunction after myocardial infarction (MI). However, molecules involved in this process have not been thoroughly elucidated. In this study we investigated the long-term effects of the growth factor midkine (MK) in cardiac remodeling after MI. MI was produced by ligation of the left coronary artery. MK expression was progress...

A sequence (Mk) of closed subsets of Rn converges normally to M ⊂ Rn if (sc) M = lim supMk = lim inf Mk in the sense of Painlevé–Kuratowski and (nc) lim sup G(NMk ) ⊂ G(NM ), where G(NM ) (resp., G(NMk )) denotes the graph of NM (resp., NMk ), Clarke’s normal cone to M (resp., Mk). This paper studies the normal convergence of subsets of Rn and mainly shows two results. The first result states t...

Menaquinone-7 (MK-7), a member of the vitamin K2 family, performs several functions, all related to its recognised effect on post-translational carboxylation of certain protein-bound glutamate residues. Due to its lipophilic structure MK-7 is soluble in olive oil, so the aim of the present study was to test whether extra-virgin (EV) olive oil enriched with MK-7 significantly increases MK-7 plas...

These experiments observed the immediate and long-term effects of neonatal treatment with MK-801 on patterned single alternation (PSA), a form of nonspatial, memory-based learning. Rat pups were injected daily on postnatal days (PND) 7-19, with MK-801 (MK+) or the less active isomer of MK-801 (MK-) (0.25 mg/kg), and trained at either PND 22 or 60. Rats treated with MK+ or MK- and trained on PND...