Background. Methicillin-resistant Staphylococcus aureus (MRSA) bacteremia (MRSAB) is associated with significant morbidity and mortality. Vancomycin (VAN) is the drug of choice for MRSAB, optimization of VAN dosing is challenging in the setting of an elevated MIC (>1-2mcg/ml). Daptomycin (DAP) is an alternative for MRSAB, however DAP MICs tend to be elevated among patients with elevated VAN MIC...

Muropeptides are fragments of peptidoglycan that trigger innate immune responses by activating nucleotide-binding oligomerization domain (NOD) 1 and NOD2. Muropeptides from Gram-negative bacteria contain a meso-diaminopimelic acid (meso-DAP) residue in either a terminal or a non-terminal position. While the former ones are known to be recognized by NOD1, much less is known about recognition of ...

Van Lunteren, Erik, and Michelle Moyer. Effects of DAP on diaphragm force and fatigue, including fatigue due to neurotransmission failure. J. Appl. Physiol. 81(5): 2214– 2220, 1996.—Among the aminopyridines, 3,4-diaminopyridine (DAP) is a more effective K1 channel blocker than is 4-aminopyridine (4-AP), and, furthermore, DAP enhances neuromuscular transmission. Because 4-AP improves muscle cont...

Dystrophin is a multidomain protein that links the actin cytoskeleton to laminin in the extracellular matrix through the dystrophin associated protein (DAP) complex. The COOH-terminal domain of dystrophin binds to two components of the DAP complex, syntrophin and dystrobrevin. To understand the role of syntrophin and dystrobrevin, we previously generated a series of transgenic mouse lines expre...

Specific three-point hydrogen bonding between diamidopyridine (DAP) and thymine (Thy) was employed to reversibly anchor "brush-like" Tri-DAP end-functionalized polystyrene onto Thy-modified silica surfaces.

We consider the problem of exploiting non-determin-istic dependent and-parallelism (DAP) from Prolog programs. The main issues that arise in designing a parallel Prolog system for exploiting DAP are discussed. Three criteria for eecient exploitation of DAP are also developed. These criteria are then used to evaluate and classify existing execution models proposed for exploiting DAP. These crite...

We propose Discovering Novel Anomalous Patterns (DAP), a new method for continual and automated discovery of anomalous patterns in general datasets. Currently, general methods for anomalous pattern detection attempt to identify data patterns that are unexpected as compared to “normal” system behavior. We propose a novel approach for discovering data patterns that are unexpected given a profile ...

A detailed study of radiation doses received by 168 patients who underwent coronary angiography (CAG) and 102 patients who underwent percutaneous transluminal coronary angioplasty (PTCA) in two Greek hospitals is presented. Radiation dose was measured in terms of dose-area product (DAP). The contribution of fluoroscopy and cineradiography to the total DAP was examined separately for each radiol...

The purpose of this work has been to dosimetrically investigate four fluoroscopically guided interventions: the percutaneous vertebroplasty (PVP), the percutaneous disc decompression (PDD), the radiofrequency medial branch neurolysis (RF) (hereafter named spine procedures), and the endovascular treatment for the critical limb ischemia (CLI). The X-ray equipment used was a Philips Integris Allur...