a new series of n-[2-(1h-1,2,3-benzotriazol-1-yl)ethyl]-4-(substitutedphenyl)-3-chloro-2-oxo-1-iminoazetidine, compounds 4(a-j) were synthesized. the structures of all the synthesized compounds were confirmed by chemical and spectral analyses such as ir, 1h nmr, 13c nmr and fab-mass. the compounds 4(a-j) were screened for their antibacterial, antifungal and antitubercular activities and gave ac...

: 1h nmr spectra of a series of enaminones r-co-ch=c(nhch2ph)-r  [1, r=ch3; 2, r=c6h5; 3, r=cf3; 4, r=ch2ch2ch2; 5, r=ch2c(ch3)2ch2], were obtained in the presence of trifluoroacetic acid in cdcl3 or dmso-d6 at 28 °c. steric, solvent, electronic and hydrogen bonding effects on the rates of acid-catalyzed nh proton exchanges were investigated. rate constants were calculated by 1h nmr line shape ...

BACKGROUND The diagnosis of inborn errors of purine and pyrimidine metabolism is often difficult. We examined the potential of 1H-NMR as a tool in evaluation of patients with these disorders. METHODS We performed 1H-NMR spectroscopy on 500 and 600 MHz instruments with a standardized sample volume of 500 microL. We studied body fluids from 25 patients with nine inborn errors of purine and pyri...

The structure of a novel antibiotic, epiderstatin, was determined as 4-[3-((Z)-3,5-dimethyl-2-oxopiperidin-6-ylidene)-2-oxopropyl]-2, 6-piperidinedione by spectroscopic analyses of 1H NMR, 13C NMR, 1H-1H correlation spectroscopy (COSY), 13C-1H COSY, heteronuclear multiple bond correlation spectroscopy, UV and IR spectra. The antibiotic belongs to the glutarimide antibiotics, however, the charac...

Phenyliodine(III) diacetate-induced oxidation of 2-(2-hydroxynaphthyl)benzoxazoles in alcohols, regioselectively afforded dearomatized products: 1-(benzoxazol-2-yl)-1-alkoxynaphthalen-2(1H)-ones and 1-(benzoxazol-2-yl)naphthalene-2,3-diones. Further, these products were also synthesized one-pot either from (E)-1-(((2-hydroxyphenyl) imino)methyl)naphthalen-2-ol or 2-aminophenol 2-hydroxynaphthal...

The title compound, 4-amino-5-benzoyl-1-benzyl-2-(4,5,6,7-tetrahydro-1H-indol-2-yl)- 1H-pyrrole-3-carbonitrile, was synthesized for the first time in a 40% yield by reaction of N-benzyl-3-imino-5,6,7,8-tetrahydro-3H-pyrrolo[1,2-a]indol-1-amine and 1-chloroacetophenone K2CO3/MeCN system (reflux, 6 h). product characterized 1H-NMR, 13C-NMR, IR spectroscopy, elemental analysis.

ةـصلاخلا : تاملاكملا لوبقب مكحتلا تايمزراوخ نم ةضيرع ةحيرشل اًماع اًراطإ ةيثحبلا ةقرولا هذه مدقت . مدقت امآ ةيمقرلا تاعرسلا تاذ لاوجلا تاكبش يف ةمدختسملا تايمزراوخلا نم ديدعلا ءادلأ اًيضاير اًيليلحت اّميقت ةقرولا مدقملا راطلإا نم ةصاخ تلااح يه يتلاو ةددعتملا . ءاطعلإ ةفلتخم تايلآ تايمزراوخلا مدختست ام ةداع نم ،تاملاكملا نم ةفلتخملا عاونلأل ةمدخلا تانامض نم ةفلتخم تايوتسم ةدناسمل كلذ و تامولعملل تاي...

Residual heteronuclear dipolar couplings obtained from partially oriented protein samples can provide unique NMR constraints for protein structure determination. However, partial orientation of protein samples also causes severe 1H line broadening resulting from residual 1H-1H dipolar couplings. In this communication we show that band-selective 1H homonuclear decoupling during data acquisition ...

دیکچ ه باس فده و هق : ب یناوجون نارود رد هیذغت تیعضو یسررب ه زا ،نارود نیا رد یراتفر و یکیزیف تارییغت تعسو لیلد ب تیمها ه تسا رادروخرب ییازس . یذغتءوس نزو هفاضا ،یرغلا ،یقاچ زا معا ه هیذغت یدق هاتوک و یناوـجون نارود رد یا صخاش نییعت رد ب نارود رد یرامیب عون و ریم و گرم یاه م یلاسگرز ؤ تـسا رث . لماوـع تاـعلاطم زا یرایسـب لـثم ی هتسناد طبترم هیذغت عضو اب بسانم ییاذغ تاداع داجیا و یتفایرد یفاضا...

BACKGROUND Flunarizine dihydrochloride (FLN) is used in the prophylactic treatment of migraine, vertigo, occlusive peripheral vascular disease and epilepsy. Cyclodextrins (CDs) are chiral, truncated cone shaped macrocycles known for their inner hydrophobic and outer hydrophilic site. They form complexes with hydrophobic drug molecules and enhance the solubility and bioavailability of such compo...