Despite the fact that pharmacokinetic exposure of kinase inhibitors (KIs) is highly variable and clear relationships exist between exposure and treatment outcomes, fixed dosing is still standard practice. This review aims to summarize the available clinical pharmacokinetic and pharmacodynamic data into practical guidelines for individualized dosing of KIs through therapeutic drug monitoring (TD...

Wearable and implantable Electrocardiograph (ECG) devices are becoming prevailing tools for continuous real-time personal health monitoring. The ECG signal can be contaminated by various types of noise and artifacts (e.g., powerline interference, baseline wandering) that must be removed or suppressed for accurate ECG signal processing. Limited device size, power consumption and cost are critica...

We report cases of unexpected adverse fetal outcome from monitored labors in which the fetal heart rate tracing was interpreted as reassuring. In these cases, portions from another signal source, usually maternal, were imperceptibly substituted into the fetal tracing in a way that masked the evidence of fetal compromise.

I t has long been appreciated that a patient’s physiological status is dynamic and subject to rapid, life-threatening changes during surgery Anesthesiologists routinely use extensive physiological monitoring to maintain the patient’s homeostasis. This monitoring can be thought of as establishing a control loop between the anesthesiologist and patient for the purposes of life support. Some infor...

Nanocomposite of polyaniline (PAn) containing nanometre size Sb2O3 was prepared in aqueous media in situ chemical oxidative polymerization method at room temperature in the presence of hydroxypropylcellulose (HPC) as a surfactant. The ability of product to removal of lead ions from aqueous solution was studied. The chemical structure and morphology were studied by fourier transform infrared (FT...

the state of works of art exhibited inside museums can be strongly influenced by indoor air quality, due to chemical activity of gaseous pollutants and particulate matter. for that reason it is important to carry out periodic air quality controls to check if the concentration levels of air pollutants comply with the limits specified by the national laws. in this work we show results obtained i...

production of electricity for promotion of people’s welfares is inevitable.there are about 54000 mw of various power plants in iran. the type of power plants includes gas, steam, combined, hydro and a very minute amount of wind mills. the per capita electricity production is about 2200 kwh. power plants can impose adverse environmental impacts during construction and utilization phases. envir...

drought detecting is a necessary aspect of drought risk management. it is generally performed usingdifferent drought indices that are effectively continuous functions of rainfall and other hydro- meteorologicalvariables. a number of drought indices have been introduced and used in various countries to date. in thecurrent research, four meteorological drought indices including the standardized p...

currently much debate, attention and concern surrounds the use of genetically modified plants or animals. but there has not been much concern about microorganisms, although we all are aware of the place of microorganisms in the circle of life, their abundance and diversity. there are many examples regarding the application of genetically engineered microorganisms (gems), however, like other hig...