BACKGROUND The association between cannabis and psychosis has long been a matter of debate, with cannabis widely perceived as a harmless recreational drug. METHODS Electronic bibliographic databases like PubMed and Google Scholar were searched using the format "(psychosis or schizophrenia or synonyms) and (cannabis or synonyms)". Cross-linked searches were made taking the lead from key articl...

Aberrant salience is likely to be a key mechanism in the development of psychosis. This concept bridges perceptual and cognitive levels but little known about their respective roles emergence It has also been suggested that not all aspects aberrant are specific The aim this study was compare patients with psychosis, other psychiatric diagnoses healthy, non-clinical participants on several psych...

Psychosis is common in Alzheimer's disease (AD). However, studies on neuropathology in vascular etiology contributing to psychosis in AD is lacking to date. The aim of this study was to investigate neuropathological vascular related changes in Alzheimer's disease with psychosis. Data of patients with AD from the National Alzheimer's Coordinating Center between 2005 to September 2013 was accesse...

Frequency and mechanisms underlying the association between narcolepsy type 1 (NT1) and psychosis remain unclear with potential role for a common immune pathway. We estimated the frequency of psychosis and its characteristics in NT1 at two European sleep centers (France, n = 381; Spain, n = 161) and measured IgG autoantibodies that recognize the GluN1 subunit of the NMDAR in 9 patients with NT1...

A correlational study examined the suppositions of Headey and Wearing’s fourdimension model of subjective wellbeing (SWB) and psychological distress amongst people experiencing psychosis. The research objective was to replicate the model with the studied sample and to examine how emotional distress resulting from psychosis affects the individuals’ satisfaction with life and positive affect leve...

Neurocognitive dysfunction is well established in psychosis, but recent work suggests that processing speed deficits might represent a particularly important cognitive deficit. A number of significant confounds, however, such as disease chronicity and antipsychotic medication use, have been shown to affect processing speed, causing debate as to the core cognitive features of psychosis. We adopt...

BACKGROUND Formal thought disorder is a cardinal feature of psychosis. However, the extent to which formal thought disorder is evident in ultra-high-risk individuals and whether it is linked to the progression to psychosis remains unclear. AIMS Examine the severity of formal thought disorder in ultra-high-risk participants and its association with future psychosis. METHOD The Thought and La...

OBJECTIVE Schizophrenia is associated with increased infections across the lifespan. We previously found an association between urinary tract infection (UTI) and acute nonaffective psychosis. The aims of this study were to explore further the relationship between UTI and acute psychosis, including associated clinical features. METHOD We identified by chart review subjects aged 18-64 years who...

OBJECTIVES Neurocognitive dysfunction is milder in bipolar disorders than in schizophrenia spectrum disorders, supporting a dimensional approach to severe mental disorders. The aim of this study was to investigate the role of lifetime history of psychosis for neurocognitive functioning across these disorders. We asked whether neurocognitive dysfunction in bipolar and schizophrenia spectrum diso...

The objective of this study was to replicate the association between atypical handedness and psychosis-proneness in a representative sample of adolescents from the general population. It expands previous studies by (1) analyzing a variety of atypical handedness indexes (left, mixed, ambiguous, and inconsistent), (2) measuring comprehensively the multidimensionality of psychosis-proneness, and (...