Due to its endogenously high oxygen consumption, the central nervous system (CNS) is vulnerable oxidative stress conditions. Notably, activity of several CNS-targeting compounds, such as antidepressant and hypnotic drugs, or endogenous mediators, melatonin, indeed linked their ability mitigating stress. In this work, we report synthesis two organoselenium compounds which structure was inspired ...

Zolpidem, zopiclone, and zaleplon are commonly referred to as the "Z-drugs." The Z-drugs are nonbenzodiazepine hypnotics indicated for the short-term treatment of insomnia. Since becoming widely prescribed as sleep aids in the United States, they are increasingly being detected in a variety of forensic specimens. We present a comprehensive overview of the basic chemistry, pharmacodynamics, and ...

Characteristic changes in brain activity accompany the paradoxical increase in alertness observed in some patients with severe brain injury when they are treated with the sleeping pill zolpidem.

Zolpidem is a newer Non-Benzodiazepine hypnotic which act at GABA-BDZ complex and widely in use for sleep disturbances. A number of side effects have been mentioned in literature i.e. dizziness. Abdominal pain, amnesia, anxiety, insomnia and other rare side effects like stupor, syncope, tremors, abnormal thinking, anaphylactic shock, delusion, dementia, depersonalisation, panic attacks, illusio...

The current study examined behavioral effects and possible development of physical dependence after once-daily doses of zolpidem (0, 1.0, 3.2, 10.0, 32.0 mg/kg intragastrically [i.g.]) in three baboons. Each dose was administered for 17 days and then the dose was increased; the 32.0 mg/kg dose was administered for 27 days. Baboons had access to food pellets for 20 hr/day beginning 15 min after ...

In Parkinson's disease (PD), elevated beta (15-35Hz) power in subcortical motor networks is widely believed to promote aspects of PD symptomatology, moreover, a reduction in beta power and coherence accompanies symptomatic improvement following effective treatment with l-DOPA. Previous studies have reported symptomatic improvements that correlate with changes in cortical network activity follow...