Introduction: Today Nano-medicine tries to produce new drugs to reduce the dosage and side effects of their conventional forms. According to the interaction between zinc and opioidergic system activity, this study has investigated the effect of new kind of zinc supplement, nano zinc oxide (nZnO), in compared to its conventional form (cZnO), in presence and absence of opioidergic system activity...

The results of foliar fertilization spring wheat crops Struna myronivska variety with aqueous solutions zinc, manganese and their chelated analogues in EDTA (zinc complexates) at different stages plant growth development are presented. research was conducted on sodmedium podzolic gley sandy soils Polissia contaminated by radionuclides after the Chernobyl accident. On average, 2014–2016 yy. plan...

Superantigens are bacterial or viral proteins that elicit massive T cell activation through simultaneous binding to major histocompatibility complex (MHC) class II and T cell receptors. This activation results in uncontrolled release of inflammatory cytokines, causing toxic shock. A remarkable property of superantigens, which distinguishes them from T cell receptors, is their ability to interac...

Cobalamin-independent methionine synthase (MetE) catalyzes the synthesis of methionine by a direct transfer of the methyl group of N5-methyltetrahydrofolate (CH3-H2PteGlun) to the sulfur atom of homocysteine (Hcy). We report here the first crystal structure of this metalloenzyme under different forms, free or complexed with the Hcy and folate substrates. The Arabidopsis thaliana MetE (AtMetE) c...

Metal-responsive transcription factor-1 (MTF-1) is an evolutionarily conserved zinc finger protein that activates transcription in response to heavy metals such as Zn(II), Cd(II) and Cu(I). The DNA-binding domain of MTF-1 recognizes a specific DNA sequence termed the metal response element (MRE), located in the promoter/enhancer region of its target genes. Here we show that human MTF-1 forms ho...

Cold-light bleaching treatment has grown to be a popular tooth whitening procedure in recent years, but its side effect of dental enamel demineralization is a widespread problem. The aim of this study was to synthesize zinc-substituted hydroxyapatite as an effective biomaterial to inhibit demineralization or increase remineralization. We synthesized zinc-substituted hydroxyapatite containing di...

The G-protein coupled receptor 83 (GPR83) is an orphan G-protein coupled receptor for which the natural ligand(s) and signaling pathway(s) remain to be identified. Previous studies suggest a role of GPR83 in the regulation of thermogenesis and the control of circulating adiponectin. The aim of this study was to gain insights into the molecular underpinnings underlying GPR83 signaling. In partic...

Background. Zinc deficiency occurs in infants when its demand exceeds its supply. It presents with cutaneous signs which, in severe cases, are associated with diarrhea, alopecia, and irritability. Genetic and acquired forms of zinc deficiency have been reported and often overlap clinical features. Malnutrition, prematurity, malabsorption syndromes, and burns may cause an increased demand for zi...