Background: Recent advances showed that oxygen radicals and hydrogen peroxides are linked with the development of several pathological processes associated with chemotherapy, including adverse effects of anti-tumor drugs. Methotrexate (MTX) is an antifolate that is widely used in the treatment of rheumatic disorders and malignant tumors. The efficacy of methotrexate is often limited by severe s...

We review some of the recent experimental results obtained at high-energy colliders with emphasis on LEP and SLC results.

Using waste products is a promising and sustainable alternative to conventional non-renewable peat nutrient-rich renewable materials. Their are gaining importance for closing the loop in ornamental plant industry. Porous inorganic materials have recently become potential bulking agents (BA) sewage sludge (SS) owing their high porosity, surface area, passivation capacity, recycling potential, po...

For a group G, embedded in its of permutations B=Perm(G) via the left regular representation λ:G→B, normalizer λ(G) B is Hol(G), holomorph G. The set ℋ(G) those N≤Hol(G) such that N≅G and NormB(N)=Hol(G) keyed to structure so-called multiple NHol(G)=NormB(Hol(G)), conjugates by NHol(G). We wish generalize this considering certain

The present study was designed to investigate the central nervous system activity of 23 novel phenylpiperazine pyrrolidin-2-one derivatives. These compounds had marked antiarrhythmic and hypotensive activities and revealed affinity for α1- and α2-adrenoceptors. These effects may be related to their α-adrenolytic properties. We assessed their antidepressant-like effect in the forced swimming tes...

The role of erythropoietin (EP) in polycythemia vera (PV) is controversial, with some experiments suggesting that erythroid progenitors in PV are exquisitely sensitive to EP and EP dependent, and others suggesting that PV progenitors are EP independent. We have examined the characteristics of the EP receptor (EP-R) on erythroid colony-forming cells (ECFC) from patients with PV. In contrast to n...

A thin film of epinephrine (EP) was electrochemically deposited on the surface of glassy carbon electrode previously activated in NaHCO3 solution. The cyclic voltammograms of the modified electrode indicate that the surface confined EP are strongly dependent on the solution pH, as expected for quinone/hydroquinone functionalities. The EP-modified glassy carbon electrode exhibited...

The objective of this study was to determine the effects of plane of nutrition during early and mid-pregnancy on the performance of mature ewes and their offspring. From day 0 to day 39 post mating (early pregnancy, EP), 82 multiparous ewes were fed to provide either 60% (low, L), 100% (medium, M) or 200% (high, H) of predicted metabolisable energy (ME) requirements for maintenance, following a...