BACKGROUND Disability-Adjusted Life Years (DALYs) have the advantage that effects on total health instead of on a specific disease incidence or mortality can be estimated. Our aim was to address several methodological points related to the computation of DALYs at an individual level in a follow-up study. METHODS DALYs were computed for 33,507 men and women aged 20-70 years when participating ...

OBJECTIVE Traumatic brain injury (TBI) is a major cause of death and disability, leading to great personal suffering and huge costs to society. Integrated knowledge on epidemiology, economic consequences and disease burden of TBI is scarce but essential for optimizing healthcare policy and preventing TBI. This study aimed to estimate incidence, cost-of-illness and disability-adjusted life years...

1Department of General Psychiatry 1, Institute of Mental Health, Singapore 2Offi ce of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore 3Schizophrenia Division, Centre for Addiction and Mental Health, Canada 4Neuroscience & Behavioral Disorders, Duke-NUS Graduate Medical School, Singapore 5Department of Psychiatry, University of Toronto, Canada Address for Correspondence: Dr Jimmy...

BACKGROUND Gastrointestinal and liver diseases (GILDs) are major causes of death and disability in Middle East and North Africa (MENA). However, they have different patterns in countries with various geographical, cultural, and socio-economic status. We aimed to compare the burden of GILDs in Iran with its neighboring countries using the results of the Global Burden of Disease (GBD) Study in 20...

It was proposed previously that the FHA2 domain of the yeast protein kinase Rad53 has dual specificity toward pY and pT peptides. The consensus sequences of pY peptides for binding to FHA2, as well as the solution structures of free FHA2 and FHA2 complex with a pY peptide derived from Rad9, have been obtained previously. We now report the use of a pT library to screen for binding of pT peptides...

BACKGROUND The epidemic of HIV/AIDS and treatments that have emerged to alleviate, have brought about a shift in the burden of disease from death to quality of life/disability. The aim was to determine which factors are associated with improvements in the level of health of male and female patients with HIV/AIDS in Andalusia, in terms of disability-adjusted life years. METHODS Descriptive stu...

OBJECTIVES To estimate the burden of disease attributable to sexually transmitted infections (STIs) in South Africa, to identify the factors contributing to this burden, and to review successes and failures in reducing this burden. DESIGN Years of life lost (YLL) and years lived with disability (YLD) were estimated using different approaches for HIV/ AIDS, other STIs and cervical cancer. Burd...