High-throughput functional and genomic screening techniques provide systematic means for phenotypic discovery. Using synthetic lethality (SL) as a paradigm anticancer drug target discovery, we describe how these technologies may offer new possibilities to identify therapeutically relevant selective SL interactions by addressing some of the challenges that have made robust discovery candidates d...

•Inhibition of SRC, PKC, and WNT consolidates human naive pluripotency induction•Competitiveness p53 depleted PSCs in cross-species chimeric embryos•Opposing net effect for ACTIVIN on mouse versus pluripotency•2i ERKi independent alternative naive-like PSC conditions Isolating MEK/ERK signaling-independent pluripotent stem cells (PSCs) with characteristics while maintaining differentiation comp...

•Surface-enhanced Raman spectroscopy reveals that aromatic hydrocarbons adsorb spontaneously to Au and Ag colloids•Density functional theory co-adsorb alongside capping ligands•The ?-metal interaction is prohibited by surface oxidation of the nanosurfaces•Recognizing on IB metals paves way for new nanotechnologies The interactions between aryl molecules are ubiquitous in nanotechnology have dir...

|Full Text: PDF (444 KB) 13. The history of noise [on the 100th anniversary of its birth] Cohen, L. Signal Processing Magazine, IEEE Volume 22, Issue 6, Date: Nov. 2005, Pages: 2045 Digital Object Identifier 10.1109/MSP.2005.1550188 Abstract |Full Text: PDF (1322 KB) 14. Low-power-consumption direct-conversion CMOS transceiver for multi-standard 5-GHz wireless LAN systems with channel bandwidth...

Tumour development driven by inflammation is now an established phenomenon but the role that complement plays remains uncertain. Recent evidence has suggested that various components of the complement (C) cascade may influence tumour development in disparate ways; however, little attention has been paid to that of the membrane attack complex (MAC). This is despite abundant evidence documenting ...

26 Interferon (IFN)-β is a major component of innate immunity in mammals, but information on 27 the in vivo source of this cytokine after pathogen infection is still scarce. To identify the cell 28 types responsible for IFN-β production during viral encephalitis, we used reporter mice that 29 express firefly luciferase under control of the IFN-β promoter and stained organ sections with 30 lucif...

Single-Ig-interleukin-1 related receptor (SIGIRR) is a member of the interleukin (IL)1/Toll-like receptor (TLR) family. It negatively regulates inflammation, rendering SIGIRR /mice more susceptible to inflammatory challenge. This susceptibility extends to the brain, where increased responsiveness to lipopolysaccharide (LPS) has been observed in SIGIRRdeficient mice. While this is likely due to ...