D-xylitol is a naturally-occurring five-carbon sugar alcohol. It can also be derived from the chemical reduction of D-xylose. It is widely used in recent years and will continue to be used as a food additive and sweetening agent in the food industry. The qualitative detection and quantification of D-xylitol in the presence of other sugars and sugar alcohols in fruits, vegetables and other natur...

Xylitol is a polyalcohol which is a regular intermediary product of the carbohydrate metabolism.1 Although there have been many reports on the effects of xylitol on the carbohydrate metabolism in animals and human beings,2,3 there have been few published data on the metabolic changes induced by the adminis tration of xylitol in acute and subacute liver injury. Accordingly, studies were undertak...

Xylitol is widely used as a sweetener in foods and medications. Xylitol ingestion causes a small blood glucose rise, and it is commonly used as an alternative to high-energy supplements in diabetics. In previous studies, a xylitol metabolite, xylulose-5-phosphate, was shown to activate carbohydrate response element binding protein, and to promote lipogenic enzyme gene transcription in vitro; ho...

OBJECTIVE As regular administration of xylitol had been effective in preventing acute otitis media (AOM) in children, we tested whether xylitol administered only at times of acute respiratory infection (ARI) reduces the occurrence of AOM. METHODS Healthy children (N = 1277) were recruited from child care centers and randomized after screening with tympanometry to receive either control mixtur...

BACKGROUND Xylitol, a commonly used sweetener, is effective in preventing dental caries. As it inhibits the growth of pneumococci, we evaluated whether xylitol could be effective in preventing acute otitis media (AOM). DESIGN Altogether, 857 healthy children recruited from day care centers were randomized to one of five treatment groups to receive control syrup (n = 165), xylitol syrup (n = 1...

In the attempt to lower the sugar consumption in population is to exchange the number of sugar sweeteners which manufacture produced for used in foods, drinks and candy with non-sugar sweetener as xylitol. Xylitol is effective as noncariogenic substitutes for use in place of glucose. Objectives: A clinical trial was carried out to investigate the effect of sugar candy containing xylitol inhibit...

Dietary xylitol supplementation increases bone calcium and phosphorus concentrations in healthy rats, as well as protects against the decrease of bone minerals and bone density during experimental osteoporosis. This suggests that dietary xylitol might have a favorable effect on the prevention of osteoporosis. However, before any conclusions can be drawn about the usefulness of a compound, studi...

BACKGROUND Xylitol, a polyol sugar, has been shown to reduce dental caries when mixed with food or chewing gum. This study examines the taste acceptability of xylitol in milk as a first step toward measuring the effectiveness of xylitol in milk for the reduction of dental caries in a public health program. METHODS Three different types of milk (Ultra High Temperature (UHT), powder and evapora...

The purpose was to evaluate the microbiological mechanism of action of xylitol and to assess its use in clinical practice for preventing acute otitis media (AOM). To test whether the effect of xylitol on S. pneumoniae is inhibited by fructose, a total of 20 strains of S. pneumoniae were exposed to xylitol in the presence of fructose and other carbon sources. Addition of 5% xylitol to the media ...

The most widely used sugar alcohols are: xylitol, sorbitol, mannitol, maltitol, lactitol and the products Lycasin® and Palatinit®. It is often claimed that xylitol is superior to the other sugar alcohols for caries control. This paper examines clinical studies on the caries-preventive and therapeutic effects of sugar alcohols with emphasis on sorbitol and xylitol. It is concluded that chewing s...