Calmodulin (CaM) binds to the skeletal muscle ryanodine receptor Ca(2+) release channel (RyR1) with high affinity, and it may act as a Ca(2+)-sensing subunit of the channel. Apo-CaM increases RyR1 channel activity, but Ca(2+)-CaM is inhibitory. Here we examine the functional effects of CaM oxidation on RyR1 regulation by both apo-CaM and Ca(2+)-CaM, as assessed via determinations of [(3)H]ryano...

BACKGROUND While cam resection is essential to achieve a good clinical result with respect to femoroacetabular impingement (FAI), it is unclear whether it should also be performed in cases of borderline developmental dysplasia of the hip (DDH) with a cam deformity. The aim of this study was to evaluate improvements in range of motion (ROM) in cases of cam-type FAI and borderline DDH after virtu...

background: contralateral axillary metastasis (cam) is a rare entity in patients with breast cancer which can occur during the primary breast cancer or its follow-up. different treatment modalities include surgery, radiotherapy, and chemotherapy, but there is no agreement on them. in our review, we found 12 series with available data, 82 patients with synchronous or metachronous contralateral a...

photosynthetic characteristics and induction of crassulacean acid metabolism (cam) by drought stress were investigated in sedum album, sedum stoloniferum and rosularia elymaitica from crassulaceae. titratable acidity, malate content, phosphoenolpyruvate carboxylase (pepc) activity and gas exchange parameters were determined in plants at the end and beginning of the photoperiod. results showed t...

The activation of Ca2+/calmodulin (CaM)-dependent protein kinase II (CaM-KII) by Ca2+/CaM results in autophosphorylation and the generation of Ca2+/CaM-independent enzyme activity. We postulated that CaM binding and subsequent autophosphorylation alters the conformation of CaM-KII and exposes its substrate-binding and catalytic site(s). Previous peptide mapping studies on CaM-KII demonstrated t...

The potential relationship of cell adhesion to embryonic induction during feather formation was examined by immunohistochemical analysis of the spatiotemporal distribution of three cell-adhesion molecules (CAMs), neural CAM (N-CAM), liver CAM (L-CAM), and neuron-glia CAM (Ng-CAM), and of substrate molecules (laminin and fibronectin) in embryonic chicken skin. The N-CAM found at sites of embryon...

AIMS To examine policies and practices relating to the provision, prescription and monitoring of complementary and alternative medicine and therapies (CAM) in conventional cancer services in NSW. METHODS Self-administered questionnaire sent to directors of all 65 eligible cancer services in NSW in 2009. RESULTS Forty-three services responded to the survey (response rate 66%). Only six (14%)...

-----------------------------------------------------ABSTRACT----------------------------------------------------Xanthan gum is a natural polysaccharide having an industrial importance. It is commonly called as heteropolysaccharide which is produced by Xanthomonas campestris. In the present investigation Xanthan gum fermentation by local isolates of Xanthomonas campestris NRRL-B-1449 from sugar...

The altered calcium binding activity of calmodulins (CaM) with point mutations can be restored toward that of wild type CaMs by the formation of a complex between CaM and a CaM binding sequence. Three different site-specific mutations resulted in selective effects on the apparent stoichiometry and affinity of CaM for calcium, with maintenance of the ability to activate myosin light chain kinase...