background pentavalent antimonials remain the choice of treatment for leishmaniasis, despite their toxicity, high cost, and difficult administration. as an alternative, morphine may induce the healing process of cutaneous leishmaniasis by its immunoregulatory characteristics. objectives to study the effect of morphine on the wound-healing process of cutaneous leishmaniasis (cl) in a mouse model...

Objective(s) The process of wound healing involves tightly integrated events including inflammation, granulation tissue formation and remodeling. Systemic administration of L-arginine promotes wound healing but its global side effects are undesirable. To confine the action of L-arginine at the site of injury, we tested the effects of local administration of L-arginine on the healing of excisio...

In more than a decade of clinical use of electrical stimulation to accelerate the chronic wound healing each patient and wound were registered and a wound healing process was weekly followed. The controlled study involved a conventional conservative treatment, sham treatment, biphasic pulsed current, and direct current electrical stimulation. A quantity of available data suffices for an analysi...

BACKGROUND The presence of oxygen is necessary for normal wound healing. Oxygen has been given as a therapeutic modality to assist and speed wound healing. OBJECTIVE The objective was to summarize the role of oxygen in wound healing. MATERIALS AND METHODS A literature review of clinical and basic science studies regarding oxygen and wound healing was conducted. RESULTS Hypoxia appears to ...

iranian traditional medicine (itm) manuscripts contain prescriptions that have long been used for healing of wounds. the present study evaluates the healing effect of a poly herbal paste (php), retrieved from itm sources, containing aloe vera, commiphora myrrha and boswellia carteri using rat excision wound model. excision wounds were induced in six groups consisting of six rats each. group 1 r...

Wound care represents a significant socioeconomic burden, with over half of chronic wounds taking up to a year to heal. Measures to accelerate wound healing are beneficial to patients and also reduce the cost and burden of wound management. Epidermal grafting (EG) is an emerging option for autologous skin grafting in the outpatient setting to improve wound healing. Although several case series ...

Wound healing is a complex, highly regulated process that is critical in maintaining the barrier function of skin. With numerous disease processes, the cascade of events involved in wound healing can be affected, resulting in chronic, non-healing wounds that subject the patient to significant discomfort and distress while draining the medical system of an enormous amount of resources. The heali...

Capsule Background: To study NF-κB-activated CTCF in EGF-induced wound healing. Results: Corneal epithelial wound healing was significantly impaired because of lacking CTCF activity in NFκB-p50 mice. EGF-induced NFκB activation regulated CTCF by interacting with CTCF-promoter to increases motility, migration and wound healing. Conclusion: CTCF is a NFκB-p50-interactive target in EGF-induced cor...