BACKGROUND Stress shielding of the proximal femur has been observed in a number of conventional cementless implants used in total hip arthroplasty. Short femoral-neck implants are claiming less interference with the biomechanics of the proximal femur. The goal of this study was to investigate the changes of bone-mineral density in the proximal femur and the clinical outcome after implantation o...

BACKGROUND There is a lack of data on the long-term outcome of total hip arthroplasty procedures, as assessed by validated tools. METHODS We conducted a follow-up study to evaluate the quality of life and functionality of 250 patients an average of 16 years (range: 11-23 years) after total hip arthroplasty using a validated assessment set including the SF-36 questionnaire, Harris Hip Score, W...

Background and purpose - Psychosocial factors are important risk factors for poor outcomes in the first year after total knee replacement (TKR), however their impact on long-term outcomes is unclear. We aimed to identify preoperative psychosocial risk factors for poor outcomes at 1 year and 5 years after TKR. Patients and methods - 266 patients were recruited prior to TKR surgery. Knee pain and...

Purpose: To assess the efficacy and safety of single-dose, intra-articular (IA) administration UBX0101 in patients with painful knee osteoarthritis (OA). is a p53/MDM2 interaction inhibitor that can induce apoptosis senescent synoviocytes. Results from recent Phase 1 study (NCT03513016) suggested IA had dose-dependent, clinically meaningful effects on pain function OA. Methods: This was 2, rand...

Abstract Background Adrenomedullin (AM) is a peptide which was suggested to be involved in the pathogenesis of osteoarthritis through its anti-inflammatory and anti-apoptotic effect. AM found elevated some inflammatory rheumatic diseases as rheumatoid arthritis ankylosing spondylitis. The current study performed measure serum Adrenomodullin concentrations patients with primary knee (KOA) assess...

Background and purpose: Non selective non-steroidal anti-inflammatory drugs and ciclooxygenase 2 inhibitors provide symptoms relief in osteoarthritis (OA), but produce several adverse effects (AE), which supports the search for other options. D-002, a mixture of higher aliphatic beeswax alcohols, has been shown to produce anti-inflammatory effects experimentally. This double-blind study investi...

OBJECTIVE To evaluate the effectiveness of various orthotic treatments for patients with isolated medial compartment osteoarthritis. DESIGN Prospective cohort study with sequential interventions. SETTING University-affiliated hospital, Hong Kong. PATIENTS From December 2010 to November 2011, 10 patients with medial knee osteoarthritis were referred by orthopaedic surgeons for orthotic tre...

Osteoarthritis (OA) is the most common form of arthritis and a leading cause of disability in older adults. Conservative non-pharmacological strategies, particularly exercise, are recommended by clinical guidelines for its management. The aim of this study was to assess the effectiveness of acupressure versus isometric exercise on pain, stiffness, and physical function in knee OA female patient...

INTRODUCTION A total of 177 patients with moderate-to-severe hip or knee osteoarthritis (OA) were tested over a period of 26 weeks in a two-center, two-armed, randomized, double-blind, comparison study. The aim was to see if a combination of glucosamine sulfate (1500 mg/day) and the omega-3 polyunsaturated fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) (group A), showed ...