نتایج جستجو برای: wnt signalling and hek293t cells

تعداد نتایج: 17086001  

Journal: :EMBO reports 2007
Lars Wittler Eun-ha Shin Phillip Grote Andreas Kispert Anja Beckers Achim Gossler Martin Werber Bernhard G Herrmann

The vertebral column and skeletal muscles of vertebrates are derived from the paraxial mesoderm, which is laid down initially as two stripes of mesenchymal cells alongside the neural tube and subsequently segmented. Previous work has shown that the wingless-type MMTV integration site family (WNT), fibroblast growth factor- and Delta-Notch signalling pathways control presomitic mesoderm (psm) fo...

2016
Minsuh Kim Young-Ah Suh Ju-Hee Oh Bo Ra Lee Joon Kim Se Jin Jang

Aberrant Wnt/β-catenin signalling is implicated in the progression of several human cancers, including non-small cell lung cancer (NSCLC). However, mutations in Wnt/β-catenin pathway components are uncommon in NSCLC, and their epigenetic control remains unclear. Here, we show that KIF3A, a member of the kinesin-2 family, plays a role in suppressing Wnt/β-catenin signalling in NSCLC cells. KIF3A...

2012
Celine Pourreyron Louise Reilly Charlotte Proby Andrey Panteleyev Colin Fleming Kathleen McLean Andrew P. South John Foerster

Wnt5a is one of the so-called non-canonical Wnt ligands which do not act through β-catenin. In normal development, Wnt5a is secreted and directs the migration of target cells along concentration gradients. The effect of Wnt5a on target cells is regulated by many factors, including the expression level of inhibitors and receptors. Dysregulated Wnt5a signalling facilitates invasion of multiple tu...

2016
Vassiliki Fotaki Rowena Smith Thomas Pratt David J. Price

The ciliary margin (CM) develops in the peripheral retina and gives rise to the iris and the ciliary body. The Wnt/β-catenin signalling pathway has been implicated in ciliary margin development. Here, we tested the hypothesis that in the developing mouse retina Foxg1 is responsible for suppressing the Wnt/β-catenin pathway and restricting CM development. We showed that there is excess CM tissue...

2011
Maria V. Barbolina Rebecca J. Burkhalter M. Sharon Stack

Wnt signalling pathways have been shown to play key roles in both normal development and tumorigenesis. Progression of many human cancers is associated with defined mutations in Wnt pathway components that result in dysregulated β-catenin-mediated gene transcription. Although Wnt pathway mutations are rare in epithelial ovarian cancer (with the exception of the endometrioid histotype), accumula...

Journal: :The EMBO journal 2012
Masamichi Imajo Koichi Miyatake Akira Iimura Atsumu Miyamoto Eisuke Nishida

The Hippo signalling pathway has emerged as a key regulator of organ size, tissue homeostasis, and patterning. Recent studies have shown that two effectors in this pathway, YAP/TAZ, modulate Wnt/β-catenin signalling through their interaction with β-catenin or Dishevelled, depending on biological contexts. Here, we identify a novel mechanism through which Hippo signalling inhibits Wnt/β-catenin ...

Journal: :PLoS ONE 2007
Maja Adamska Sandie M. Degnan Kathryn M. Green Marcin Adamski Alina Craigie Claire Larroux Bernard M. Degnan

BACKGROUND The origin of metazoan development and differentiation was contingent upon the evolution of cell adhesion, communication and cooperation mechanisms. While components of many of the major cell signalling pathways have been identified in a range of sponges (phylum Porifera), their roles in development have not been investigated and remain largely unknown. Here, we take the first steps ...

2016
E. Astanina G. Doronzo F. Neri D. Valdembri G. Serini S. Oliviero A. Ballabio F. Bussolino

Background: LDL receptor-related protein 5 (LRP5) triggers the canonical Wnt pathway which participates in cell function regulation, including lipoprotein metabolism, macrophage mobility and phagocytosis, but its function in the heart is unknown. Purpose: The aim of this study was to investigate LRP5 and the canonical Wnt signalling pathway in myocardial injury after acute-myocardial infarction...

2016
Manish Kumar Nicole J. Camlin Janet E. Holt Jose M. Teixeira Eileen A. McLaughlin Pradeep S. Tanwar

All the major components of the WNT signalling pathway are expressed in female germ cells and embryos. However, their functional relevance in oocyte biology is currently unclear. We examined ovaries collected from TCFGFP mice, a well-known Wnt reporter mouse model, and found dynamic changes in the Wnt/βcatenin signalling activity during different stages of oocyte development and maturation. To ...

2014
Paulo Rodrigues Irati Macaya Sarah Bazzocco Rocco Mazzolini Elena Andretta Higinio Dopeso Silvia Mateo-Lozano Josipa Bilić Fernando Cartón-García Rocio Nieto Lucia Suárez-López Elsa Afonso Stefania Landolfi Javier Hernandez-Losa Kazuto Kobayashi Santiago Ramón y Cajal Josep Tabernero Niall C. Tebbutt John M. Mariadason Simo Schwartz Diego Arango

Activation of the small GTPase RHOA has strong oncogenic effects in many tumour types, although its role in colorectal cancer remains unclear. Here we show that RHOA inactivation contributes to colorectal cancer progression/metastasis, largely through the activation of Wnt/β-catenin signalling. RhoA inactivation in the murine intestine accelerates the tumorigenic process and in human colon canc...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید