BACKGROUND Glucocorticoid (GC)-induced osteonecrosis (ON) is an important complication of medical therapy. The exact pathomechanisms of ON has not been clearly elucidated. There is a need for a reproducible animal model that better approximates the clinical scenario. METHODS To determine the genetic susceptibility of rats to develop GC-induced femoral head ON, we evaluated 5 different inbred ...

Ethylene glycol (EG)-induced hyperoxaluria is the most commonly employed experimental regimen as an animal model of calcium oxalate (CaOx) stone formation. The variant sensitivity to CaOx among different rat strains has not been fully explored, although the Wistar rat is known to accumulate more CaOx in kidney tissue after low-dose EG exposure than in the Fischer 344 (F344) rats. Supersaturatio...

objective: dietary changes playmajor risk roles in oxidative stress andcardiovascular disease and modulate normal metabolic function. the present study was designed to investigate the ameliorative potential of different extracts of hemidesmus indicus to experimental high-fat diet in wistar rats, and their possible mechanism of action.  materials and methods: male wistar rats were divided into 6...

In Indonesia, cruciferous cabbage is known as Ceciwis (Brassica oleracea L. var. capitata f. alba Alef), a vegetable that can be consumed diet from Tegal one of the plants rich in flavonoids and phenol proposed has an antidyslipidemic ac-tivity. The purpose this study to see how affect lipid profile Wistar rats (Rattus norvegicus) fed high-fat diet. Method: Rats divided into seven groups: norma...

OBJECTIVE Streptozotocin (STZ)-induced diabetes in Wistar rats results in severe hyperlipidemia and a characteristic cardiomyopathy. However, Wistar-Kyoto (WKY) rats made diabetic with a similar dose of STZ did not develop heart dysfunction or hypertriglyceridemia at 12 weeks post-STZ. We investigated whether an apparent resistance of the WKY strain to develop diabetic cardiomyopathy and hypert...

The aim of the study was to evaluate cumulative toxic effect bleomycin under experimental conditions
 Material and Methods. conducted in Research Institute Transport Medicine during 2016-2021. model cardiotoxic performed using medication "Bleocin" manufactured by Nippon Kayaku Co., Ltd. (Japan). According task, on 10 mature rats both sexes Wistar line with a body weight 237 ± 20 g.
 R...

background: margarine contain trans fatty acids as major sources of dietary free radicals, and oxidative stress. effect of oral administration of margarine on hepatic enzyme was investigated in wistar rats. methods: thirty six (36) adult wistar rats were uniformly divided into three groups of control , margarine 15% and 20%, twelve rats in each groups (6males & 6 females). margarine was added t...

In order to reproduce chronic cerebral hypoperfusion as it occurs in human aging and Alzheimer's disease, we introduced permanent, bilateral occlusion of the common carotid arteries (BCCAO) in rats (Farkas et al, 2007). Here, we induced BCCAO in two different rat strains in order to determine whether there was a strain difference in the pathogenic response to BCCAO. Male Wistar and Sprague-Dawl...

This research was purposely to study and determine the physicochemical characteristics, sensory hypocholesterolemic effects of purple sweet potato bread made from flour, starch, fiber-rich flour starch processing waste on white male species Wistar rats conducted in vivo. used a non-factorial randomized block design model with treatment 100% standard feed, 25% mixture bread, combination 50% heal...

AIMS We investigated the effects of hypertension and acute blood pressure changes on rats' vesicovascular reflexes (VVRs). MAIN METHODS Twelve-week-old male Wistar rats and spontaneously hypertensive rats (SHRs) were anesthetized with urethane, and underwent real-time cystometry and blood pressure monitoring. The SHRs were administered nifedipine or valsartan intravenously. The Wistar rats we...