OBJECTIVE Oncofetal protein insulin-like growth factor II mRNA-binding protein 1 (IMP1) regulates cellular proliferation and migration. Expression of IMP1 is limited to a few adult human tissues. However, it commonly expresses in a variety of cancers. Our objective was to study the regulatory mechanism of IMP1 on the cellular functions of choriocarcinoma (CC) JAR cells. METHODS IMP1 protein l...

Preeclampsia is a common pregnancy complication in the latter half of gestation diagnosed by hypertension and proteinuria. A key feature of preeclampsia is an altered placentation with reduced trophoblast invasion. Normal placentation requires controlled invasion of trophoblasts into the maternal uterine wall, with secretion of specific proteolytic enzymes able to degrade basement membranes and...

The molecular mechanism that leads to pregnancy-induced hypertension (PIH), a pregnancy-specific syndrome, remains poorly understood. It has been suggested that microRNAs (miRNAs) may be potentially useful biomarkers for severe preeclampsia (PE), which is an important condition associated with PIH. The aim of the present study was to identify miR-204 by verifying differentially expressed serum ...

An anaerobic glove box designed for moderate-sized hospitals or research laboratories is described. The compact vinyl and metal enclosure becomes anaerobic rapidly after inflation, requires no vacuum pump, and provides incubator space equivalent to 15 standard anaerobic jars.

It is of great interest to find the minimum effective dose (MED) in dose-response studies. A sequence of decreasing null hypotheses to find the MED is formulated under the assumption of nondecreasing dose response means. A step-up multiple test procedure that controls the familywise error rate (FWER) is constructed based on the maximum likelihood estimators for the monotone normal means. When t...

We propose the B c → B * u γ decay as the most suitable probe for the flavour changing neutral transition c → uγ. We estimate the short and long distance contributions to this decay within the standard model and we find them to be comparable; this is in contrast to radia-tive decays of D mesons, that are completely dominated by the long distance contributions. Since the c → uγ transition is ver...

Beekeeping is an essential economy branch. Therefore, it so important to study the conditions that affect its state. The Jewish Autonomous Region (JAR) one of most melliferous regions Far East. main species here linden. Forest fires are a major negative factor in growth linden region under study. research aims at identifying and studying forests, which include linden, suitable for development b...

This study presents a novel category of Transformer architectures known as comb transformers, which effectively reduce the space complexity self-attention layer from quadratic to sub-quadratic level. is achieved by processing sequence segments independently and incorporating X -word embeddings ...