نتایج جستجو برای: wild rodent

تعداد نتایج: 186320  

2002
Christine J. Swardson-Olver Tracey C. Dawson Robert C. Burnett Stephen C. Peiper Nobuyo Maeda Anne C. Avery

Erythrocyte invasion by malaria parasites is a complex multistep process involving parasite and erythrocyte receptors. It is a critical stage in the parasite life cycle and, therefore, a logical step in which to intervene to prevent or ameliorate disease. Rodent models of malaria, commonly Plasmodium yoelii, are frequently used for studies of malaria pathogenesis. Little is known, however, abou...

2014
Lisa A. Shender Maxy De Los Santos Joel M. Montgomery Patricia A. Conrad Bruno M. Ghersi Hugo Razuri Andres G. Lescano Jonna A. K. Mazet

An estimated 2.3 million disability-adjusted life years are lost globally from leishmaniasis. In Peru's Amazon region, the department of Madre de Dios (MDD) rises above the rest of the country in terms of the annual incidence rates of human leishmaniasis. Leishmania (Viannia) braziliensis is the species most frequently responsible for the form of disease that results in tissue destruction of th...

2017
Totta Ehret Francesca Torelli Christian Klotz Amy B. Pedersen Frank Seeber

Rodents, in particular Mus musculus, have a long and invaluable history as models for human diseases in biomedical research, although their translational value has been challenged in a number of cases. We provide some examples in which rodents have been suboptimal as models for human biology and discuss confounders which influence experiments and may explain some of the misleading results. Infe...

2017
Totta Ehret Francesca Torelli Christian Klotz Amy B. Pedersen Frank Seeber

Rodents, in particular Mus musculus, have a long and invaluable history as models for human diseases in biomedical research, although their translational value has been challenged in a number of cases. We provide some examples in which rodents have been suboptimal as models for human biology and discuss confounders which influence experiments and may explain some of the misleading results. Infe...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1996
S W Curtis T Washburn C Sewall R DiAugustine J Lindzey J F Couse K S Korach

Past studies have shown that epidermal growth factor (EGF) is able to mimic the uterotropic effects of estrogen in the rodent. These studies have suggested a "cross-talk" model in which EGF receptor (EGF-R) signaling results in activation of nuclear estrogen receptor (ER) and its target genes in an estrogen-independent manner. Furthermore, in vitro studies have indicated the requirement for ER ...

Journal: :Journal of neurophysiology 2002
Yasnory F Sasaki Thomas Rothe Louis S Premkumar Saumya Das Jiankun Cui Maria V Talantova Hon-Kit Wong Xiandi Gong Shing Fai Chan Dongxian Zhang Nobuki Nakanishi Nikolaus J Sucher Stuart A Lipton

Recently, we cloned and began to characterize a new N-methyl-D-aspartate receptor (NMDAR) subunit, NR3A. Here we extend our earlier findings by showing that recombinantly expressed NR3A in COS cells is biochemically associated with both NR1 and NR2 subunits. In the oocyte or HEK 293 cell expression systems, co-injection of NR3A with NR1/NR2 subunits acts in a dominant-interfering manner, result...

Journal: :Stroke 2015
Srinivasan V Narayanan Kunjan R Dave Isa Saul Miguel A Perez-Pinzon

BACKGROUND AND PURPOSE Nuclear erythroid 2 related factor 2 (Nrf2) is an astrocyte-enriched transcription factor that has previously been shown to upregulate cellular antioxidant systems in response to ischemia. Although resveratrol preconditioning (RPC) has emerged as a potential neuroprotective therapy, the involvement of Nrf2 in RPC-induced neuroprotection and mitochondrial reactive oxygen s...

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