The Hedgehog (Hh) and Wnt signaling pathways are crucial for development as well as for adult stem cell maintenance in all organisms from Drosophila to humans. Aberrant activation of these pathways has been implicated in many types of human cancer. During evolution, organisms have developed numerous ways to fine-tune Wnt and Hh signaling. One way is through extracellular modulators that directl...

زۆربەى لێکۆڵينەوەکان کە لە سەر ناوچەى ئاکرێ نووسراون زیاتر لایەنەکانى سیاسى و کارگێڕى سەربازى دەگرێتەوە, کاتێکدا بوارە گرنگەکانى ديكه‌ى ژیان فەرامۆش کراون، بە تایبەتى لایەنى ئابوورى نێویشيدا بوارى کشتوکاڵ زەورى زار، پەیوەندى راستەوخۆى لەگەڵ ژیانى مروڤدا هەیە, سەرەڕاى ئەمەش لەچاو کەمتر بایەخى پێ دراوە, بۆیە پێمان باش بوو لەسەر ئەم بابەتە بنووسين. ئامانجى سەرەکیشمان ئەوەیە بەم لێکۆڵینەوە لایەنێکى...

BACKGROUND Using quantitative methylation-specific PCR (QM-MSP) is a promising method for colorectal cancer (CRC) diagnosis from stool samples. Difficulty in eliminating PCR inhibitors of this body fluid has been extensively reported. Here, spermidine is presented as PCR facilitator for the detection of stool DNA methylation biomarkers using QM-MSP. We examined its effectiveness with NPY, PENK ...

PURPOSE The CpG island methylator phenotype (CIMP) may be associated with development of malignancy through coordinated inactivation of tumor suppressor and tumor-related genes (TRG) and methylation of multiple noncoding, methylated-in-tumor (MINT) loci. These epigenetic changes create a distinct CIMP pattern that has been linked to recurrence and survival in gastrointestinal cancers. Because e...

Wnt signal pathway genes are known to be involved with cancer development. Here we tested the hypothesis whether DNA methylation of genes part of the Wnt signaling pathway could help the diagnosis of non-small cell lung cancer (NSCLC). The methylation levels of SFRP1, SFRP2, WIF1 and PRKCB in 111 NSCLC patients were evaluated by quantitative methylation-specific PCR (qMSP). Promoter methylation...

Previous transcriptome studies observed disrupted cellular processes in late-onset Alzheimer's disease (LOAD), yet it is unclear whether these changes are specific to LOAD, or are common to general neurodegeneration. In this study, we address this question by examining transcription in LOAD and comparing it to cognitively normal controls and a cohort of "disease controls." Differential transcri...

* ايجولونكت دهعم – دادغب , ينقتلا ميلعتلا ةئيه / دادغب ** مسق ةسدنه نداعملاو جاتنلاا , ةيجولونكتلا ةعماجلا / دادغب *** ايجولونكتلاو مولعلا ةرازو / دادغب 497 مييقت لكآتلا ةمواقم طاسوا يف ةيتيركنوكلا ةناسرخلا ةيوقت يف مدختسملا ديدحلل ةفلتخم ةيئام بوقعي فسوي ثيل * شابك ةرهزلا دبع لحز ** و حلاص دمحم قفوم *** 2010/12/21 خیرات میدقتلا : 2011/6/2 خیرات لوبقلا : ةصلاخلا ف حيلستلا ديدحل ...