BACKGROUND Ventricular arrhythmia occurrence during exercise is reported in Brugada syndrome (BrS). Accordingly, experimental studies suggest that BrS-linked SCN5A mutations reduce sodium current more at fast heart rates. Yet, the effects of exercise on the BrS ECG phenotype have not been studied. We aimed to assess ECG responses to exercise in BrS and determine whether these responses are affe...

Even though design of a widening operator is an integral step in the design of an abstract interpreter using an infinite domain, not much work has been done to systematize the design of widening operator. While there exist works that derive widening of higher-level domains by lifting the widening of the base-level domain, the design of widening for baselevel domains remains largely creative pro...

BACKGROUND QRS prolongation is associated with adverse outcomes in mostly white populations, but its clinical significance is not well established for other groups. We investigated the association between QRS duration and mortality in African Americans. METHODS AND RESULTS We analyzed data from 5146 African Americans in the Jackson Heart Study stratified by QRS duration on baseline 12-lead EC...

A 22-year-old male was brought in by paramedics who found him unresponsive at home surrounded by drug paraphernalia. He had a blood pressure of 84/50 mm Hg; oxygen saturation of 88%; irregular pulse; and Glasgow Coma Scale of 3. His skin was cool, diaphoretic and ashen in color, except for a grossly erythematous right arm. Lab work demonstrated an initial creatine kinase of 5,414 U/L that incre...

OBJECTIVE To study the possible occurrence of left ventricular (LV) systolic and diastolic asynchrony in patients with systolic heart failure (HF) and narrow QRS complexes. DESIGN Prospective study. SETTING University teaching hospital. PATIENTS 200 subjects were studied by echocardiography. 67 patients had HF and narrow QRS complexes (< or = 120 ms), 45 patients had HF and wide QRS compl...

Objective: To study the possible occurrence of left ventricular (LV) systolic and diastolic asynchrony in patients with systolic heart failure (HF) and narrow QRS complexes. Design: Prospective study. Setting: University teaching hospital. Patients: 200 subjects were studied by echocardiography. 67 patients had HF and narrow QRS complexes (< 120 ms), 45 patients had HF and wide QRS complexes (>...