BACKGROUND Whole genome sequencing (WGS) is becoming a routine tool for infectious disease outbreak investigations. The Swedish situation provides an excellent opportunity to test the usefulness of WGS for investigation of outbreaks with Salmonella Dublin (S. Dublin) as epidemiological investigations are always performed when Salmonella is detected in livestock production, and index isolates fr...

Recent advances in whole genome sequencing have made the technology available for routine use in microbiological laboratories. However, a major obstacle for using this technology is the availability of simple and automatic bioinformatics tools. Based on previously published and already available web-based tools we developed a single pipeline for batch uploading of whole genome sequencing data f...

The role of the reticulo-endothelial system (RES) in recovery following whole body X-irradiation has aroused considerable recent interest."5'17 However, ready explanation of this role is complicated by the fact that pertinent data concerning the effect of ionizing radiation upon the RES seem somewhat contradictory. 8 1, U U2"-8 Generally, the RES is regarded as a non-radiosensitive tissue.8'25 ...

We previously reported that in p53 (+ / -) mice that had been given a whole-body dose of 3 Gy at 8 weeks of age, p53-dependent delayed effects of radiation, as manifested in T-cell receptor (TCR) variant fractions (VF) instability in mouse splenocytes, were biphasic, namely, induction of TCR-VF mutation reappeared at 44 weeks. The manifestation of the delayed effects and the measures of biologi...

GST-TAT-SOD was the fusion of superoxide dismutase (SOD), cell-permeable peptide TAT, and glutathione-S-transferase (GST). It was proved to be a potential selective radioprotector in vitro in our previous work. This study evaluated the in vivo radioprotective activity of GST-TAT-SOD against whole-body irradiation. We demonstrated that intraperitoneal injection of 0.5 ml GST-TAT-SOD (2 kU/ml) 2 ...

PURPOSE Ablative bone marrow irradiation is an integral part of hematopoietic stem cell transplantation. These treatment regimens are based on classically held models of radiation dose and the bone marrow response. Flt-3 ligand (FL) has been suggested as a marker of hematopoiesis and bone marrow status but the kinetics of its response to bone marrow irradiation has yet to be fully characterized...

we conducted this study to determine the level of immunity after vaccination of lambs with whole bodyechinococcus granulosus. to do so, 200 mature e. granulosus parasites, which were kept in 10% formalinefor 8 months, were obtained from the department of parasitology, school of veterinary medicine, ferdowsiuniversity of mashhad. the soluble protein of the parasite was prepared. the sample was h...

background: drivers of heavy motor vehicles are occupationally exposed to intense whole body vibration (wbv) for several hours per day over their working lifetime. therefore, they are at risk of wbv-induced occupational disorders. this study aimed to investigate health effects of long-term exposure to whole body vibration among a group of heavy vehicle drivers in fars province, southwestern ira...

Ionizing radiation as one of the strongest cytogenetic factors can induce significant injury to adult brain. In the present study, adult male Wistar rats were exposed to single whole-body gamma irradiation with the dose of 3 Gy. One, 5, 10, 25, 40 or 80 days after irradiation, proliferating cells were labelled using BrdU immunohistochemistry. BrdU-positive cells were counted individually in the...

The relationship between the way in which normal hemopoietic stem cells respond to irradiation alone or in the presence of bleomycin sulfate (BLM-S) and actinomycin 0 (ACT-D) was investigated. Single doses of BLM-S at 0.3 mg/kg and ACT-O at 0.10 mg/kg body weight were injected intravenously 1-6 hours prior to whole body irradiation and treatment was repeated twice more with time intervals....