contraceptive patches have become a frequently used contraceptive method. we present a mathematical model that describes the serum concentration profiles of norelgestromin (ngmn) and ethinylestradiol (ee) released from the contraceptive patch ortho evra®. we propose a simple one-compartment model based on pharmacokinetics data reported in previous studies. the model assumes a time-dependent rel...

Contact allergy, viz. allergic contact dermatitis, photo-allergic contact dermatitis and contact urticaria, is a well-studied sub-specialty of dermatology in Singapore. Over the years, numerous studies and anecdotal reports on the subject have been published in both international and local refereed journals. This article reviews the epidemiological data on patch testing and photo-patch testing ...

We present a new approach to modeling contact between rigid objects that augments an individual Coulomb friction point-contact model with rolling and spinning friction constraints. Starting from the intersection volume, we compute a contact normal from the volume gradient. We compute a contact position from the first moment of the intersection volume, and approximate the extent of the contact p...

Buprenorphine is a potent semisynthetic opioid analgesic that is widely used to treat moderate to severe pain. Since 2001, it has been available in several European countries in a transdermal delivery system (TDS), and it was approved for use in the United States in 2010. We report 3 cases of allergic contact dermatitis caused by a TDS containing buprenorphine, as verified by a positive patch t...

This paper discusses the use of Linear Mixed Models (LMM) and Generalized Linear Mixed Models (GLMM) to predict the wear and damage trajectories of railway wheelsets for a fleet of modern multiple unit trains. The wear trajectory is described by the evolution of the wheel flange thickness, the flange height and the tread diameter; whereas the damage trajectory is assessed through the probabilit...

Articulated Wheeled Robotic (AWR) locomotion systems consist of chassis connected to a set of wheels through articulated linkages. Such articulated “leg-wheel systems” facilitate reconfigurability that has significant applications in many arenas, but also engender constraints that make the design, analysis and control difficult. We will study this class of systems in the context of design, anal...