Ryan J. MacDonald, MD Peter P. Stanich, MD Priya A. Monrad, MD Farrah J. Mateen, MD A 43-year-old man with chronic pancreatitis and 7-kg weight loss secondary to persistent nausea and reduced oral intake presented with double vision and gait unsteadiness. Neurologic examination revealed complete horizontal and partial vertical ophthalmoplegia with prominent gait ataxia (video 1 on the Neurology...

To assess risk for cattle-to-human transmission of prions that cause uncommon forms of bovine spongiform encephalopathy (BSE), we inoculated mice expressing human PrP Met129 with field isolates. Unlike classical BSE agent, L-type prions appeared to propagate in these mice with no obvious transmission barrier. H-type prions failed to infect the mice.

BACKGROUND In many of the European countries affected by Bovine Spongiform Encephalopathy (BSE), case clustering patterns have been observed. Most of these patterns have been interpreted in terms of heterogeneities in exposure of cattle to the BSE agent. Here we investigate whether spatial clustering is present in the Dutch BSE case data. RESULTS We have found three spatial case clusters in t...

The aim of our study was to evolve views on writing disorders in Wernicke's agraphia by comparing group data and analysis of a single patient. We showed how a single-case study can be useful in obtaining essential results that can be hidden by averaging group data. Analysis of a single patient proved to be important for resolving contradictions of the "holistic" and "elementaristic" paradigms o...

A 34-year-old man with acute lymphoblastic leukemia was admitted for management of fever, cough, sputum, and diarrhea and was treated with antibiotics including pentamidine, meropenem, and voriconazole for Pneumocystis carinii pneumonia, bacteremia, and fungal infections. One month before admission, the patient received salvage chemotherapy with high-dose cytosine arabinoside, mitoxantrone, and...