Background: Brain hypoxia-ischemia is a human neonatal injury that is considered a candidate for stem cell therapy. Methods: The possible therapeutic potential of human umbilical cord blood (HUCB) stem cells was evaluated in 14-day-old rats subjected to the right common carotid occlusion, a model of neonatal brain hypoxia-ischemia. Seven days after hypoxia-ischemia, rats received either saline ...

INTRODUCTION Left ventricular remodeling (LVR) is the most prognostically important consequence of acute myocardial infarction (AMI). The aim of the study was to assess the value of speckle tracking echocardiography in the prediction of left ventricular remodeling in patients after AMI and primary coronary angioplasty (PCI). MATERIAL AND METHODS Eighty-eight patients (F/M = 31/57 patients; 63...

Results We analyzed 352 cases of severe sepsis (33.2%) and septic shock (66.8%). The average age was 65 (range 18 to 98), and 53.1% were men. The APACHE II average score was 20.9. Lung (58% vs 43.3% p = 0.017) and bloodstream (25% vs 7.5% p < 0.001) were the most prevalent sepsis focuses in the chronic cohort, but in the acute cohort were abdomen (22.2% vs 1% p < 0.001) and urine (15.5% vs 5% p...

PURPOSE Enhanced recovery protocols are being implemented into the standard of care in surgical practice. This study aimed to insert a steadfast set of elements into the perioperative care pathway to establish an improved recovery program for colorectal cancer patients. METHODS Seventy patients planned for elective laparoscopic colorectal resection were randomized into 2 groups: conventional ...

Background: Given that few studies regarding the effect of Aloe vera (A. vera) on prevention of fever and neutropenia on acute lymphoid leukemia (ALL) disease, the aim was to evaluate the effect of A.vera on prevention of fever and neutropenia in children with ALL. Materials and Methods: This randomized clinical trial study was conducted on 60 children with mean age 5.6± 2.9 years in Oncology ...

background: erythropoietin (epo) is known as a regulating hormone for the production of red blood cells, called erythropoiesis. some studies have shown that epo exerts some non-hematopoietic protective effects on ischemia-reperfusion injuries in myocytes. using echocardiography, we evaluated the effect of epo infusion on reducing ischemia-reperfusion injuries and improvement of the cardiac func...

The effects of levosimendan on cerebrovascular lesions and mortality were investigated in models of primary and secondary stroke. We aimed to determine whether the effects of levosimendan are comparable to and/or cumulative with those of valsartan, and to investigate whether levosimendan-induced vasodilation has a role in its effects on stroke. In a primary stroke Dahl/Rapp rat model, mortality...

background and objective: to assess the effectiveness and safety of oral amiloride for the treatment of edema in pediatric patients with idiopathic nephrotic syndrome. methods: a randomized trial of amiloride vs hydrochlorthiazide was done in 34 patients. the mean age was 4.3±0.7 years old. after a 2 week washout of diuretic therapy, nephrotic children with edema were randomized into two groups...

Background: Erythropoietin (EPO) is known as a regulating hormone for the production of red blood cells, called erythropoiesis. Some studies have shown that EPO exerts some non-hematopoietic protective effects on ischemia-reperfusion injuries in myocytes. Using echocardiography, we evaluated the effect of EPO infusion on reducing ischemia-reperfusion injuries and improvement of the cardiac func...

This randomized, multicenter clinical trial enrolled 103 children hospitalized with septated parapneumonic empyema (PPE) who were randomized to receive thoracoscopy (n=53) or urokinase (n=50). The main outcome variable was the length of hospital stay after treatment. The secondary outcomes were total length of hospital stay, number of days with the chest drain, number of days with fever, and tr...