BACKGROUND 'Low-carb' diets have been suggested to be effective in body weight (BW) management. However, these diets are relatively high in protein as well. OBJECTIVE To unravel whether body-weight loss and weight-maintenance depends on the high-protein or the 'low-carb' component of the diet. DESIGN Body-weight (BW), fat mass (FM), blood- and urine-parameters of 132 participants (age=50 ± ...

An experiment using 81 crossbred swine was conducted to evaluate quantitative and percentage chemical compositional changes of swine from 1.5 kg (birth) to 145 kg body weight. Groups of eight pigs were sacrificed at 1.5, 6.4 and 18 kg, and then at 18 kg increments to 145 kg. Body composit ion was determined by grinding the entire body, minus digesta, partit ioning the carcass from other body co...

Authors’ Affi liations: 1 Divisions of Molecular Medicine and Genetics, Department of Internal Medicine, and 2 Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan Corresponding Author: Jun-Lin Guan, University of Michigan Medical School, 3027 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI 48109. Phone: 734-615-4936; Fax: 734-763-1166; E-mail: jl...

Mobilization of peripheral blood stem cells (PBSC) in healthy volunteers with granulocyte colony-stimulating factor (G-CSF) is currently carried out at many institutions worldwide. This report presents the experience of the Dresden center regarding donor evaluation and mobilization schedule. Data regarding efficacy, short- and long-term safety of G-CSF treatment gained from 8290 PBSC collection...

BACKGROUND Low birth weight and high childhood body mass index (BMI) is each associated with an increased risk of coronary heart disease (CHD) in adult life. We studied individual and combined associations of birth weight and childhood BMI with the risk of CHD in adulthood. METHODS/PRINCIPAL FINDINGS Birth weight and BMI at age seven years were available in 216,771 Danish and Finnish individu...

BACKGROUND In response to the increase in obesity, pharmacologic treatments for weight loss have become more numerous and more commonly used. PURPOSE To assess the efficacy and safety of weight loss medications approved by the U.S. Food and Drug Administration and other medications that have been used for weight loss. DATA SOURCES Electronic databases, experts in the field, and unpublished ...

BACKGROUND Flibanserin, a 5-HT1A agonist and 5-HT2A antagonist, is indicated for the treatment of acquired, generalized hypoactive sexual desire disorder (HSDD) in premenopausal women. This post hoc analysis evaluated the effect of flibanserin treatment on body weight in premenopausal and postmenopausal women with HSDD. MATERIALS AND METHODS This analysis included three 24-week, double-blind,...

We previously identified a region of mouse chromosome 7 that influences body fat mass in F2 littermates of congenic × background intercrosses. Current analyses revealed that alleles in the donor region of the subcongenic B6.C-D7Mit318 (318) promoted a twofold increase in adiposity in homozygous lines of 318 compared with background C57BL/6ByJ (B6By) mice. Parent-of-origin effects were discounte...