BACKGROUND There is a paucity of randomised controlled trials of weight management in primary care. AIM To ascertain the feasibility of a full trial of a nurse-led weight-management programme in general practice. DESIGN OF STUDY Factorial randomised control trial. SETTING Primary care, UK. METHOD A total of 123 adults (80.3% women, mean age 47.2 years) with body mass index > or =27 kg/m...

A new platelet-specific alloantigen, termed Sit(a), was identified in a severe case of neonatal alloimmune thrombocytopenia. The Sit(a) alloantigen is of low frequency (1/400) in the German population. Immunochemical studies demonstrated that the Sit(a) epitopes reside on platelet glycoprotein (GP) Ia. Nucleotide sequence analysis of GPIa cDNA derived from Sit(a)-positive platelets showed C(253...

BACKGROUND Staphylococcus aureus bacteremia (SAB) is an important infection. Methicillin-resistant S aureus (MRSA) screening is performed on hospitalized patients for infection control purposes. OBJECTIVE To assess the usefulness of past MRSA screening for guiding empirical antibiotic therapy for SAB. METHODS A retrospective cohort study examined consecutive patients with confirmed SAB and ...

OBJECTIVE To determine the association between large birth weight and the risk of developing asthma in early childhood. METHODS All single live births (n=687 194) born in Ontario between 1 April 1995 and 31 March 2001 were followed until their sixth birthday. Their birth weight was categorised as low (<2.5 kg), normal (2.5-4.5 kg), large (4.6-6.5 kg) or extremely large (>6.5 kg). Poisson regr...

BACKGROUND The Mediterranean dietary pattern might be a potential tool for the prevention of obesity. OBJECTIVES We studied the association between adherence to 6 previously published scores used to assess the adherence to the Mediterranean diet and weight change. We also assessed the risk of relevant weight gain (≥ 5 kg) or the risk of developing overweight or obesity. DESIGN The study pop...

BACKGROUND The association between obesity and depression remains equivocal. The aims of this study were to examine the association between body mass index (BMI) and depressive symptoms in the Chinese adult population. METHODS In this study, data from the Health Promotion Knowledge, Attitudes, and Performance Survey, conducted in 2002 among 20,385 Taiwanese adults (aged 18-64 years), were use...

In adults, second-generation antipsychotics (SGAs) have a low frequency of extrapyramidal syndrome (EPS) and a moderate frequency of metabolic adverse effects. Here we aimed to assess short-term adverse effects of SGAs in children and adolescents. We searched for relevant studies in MEDLINE and EMBASE (1996-2010), Food and Drug Administration and European Medicines Agency clinical trial registr...

BACKGROUND Stress has been shown to be a determinant of weight change and risk for obesity. To date, there is scarce evidence that stressful life events and their severity contribute to changes in body weight. We studied the association between the occurrence, impact of and adaptation to adverse life events and weight change and the role of initial weight status. METHODS Analyses were based o...

OBJECTIVE To examine the association between anxiety and weight change in a multiethnic cohort followed for approximately 10 years. METHODS The study population consisted of participants of the multiethnic study of atherosclerosis who met specified inclusion criteria (n = 5,799). Weight was measured at baseline and four subsequent follow-up exams. Anxiety was analyzed as sex-specific anxiety ...

BACKGROUND In the context of the increasing resistance to sulfadoxine-pyrimethamine (SP), we evaluated the efficacy of mefloquine (MQ) for intermittent preventive treatment during pregnancy (IPTp). METHODS A multicenter, open-label equivalence trial was conducted in Benin from July 2005 through April 2008. Women of all gravidities were randomized to receive SP (1500 mg of sulfadoxine and 75 m...