Hemophagocytic syndrome (HPS) is a rare condition characterized by overactive histiocytes, hepatosplenomegaly, fever and cytopenia, with two major types: familial, autosomal recessive genetic disease and acquired that can occur during systemic infections, immunodeficiency or malignancy. Inappropriate activation of macrophages by cytokines is the major mechanism of the disease. We report a case ...

Patents for the first generation of approved biopharmaceuticals have either expired or are about to expire. Thus the market is opening for generic versions, referred to as 'biosimilars' (European Union) or 'follow-on protein products' (United States). Healthcare professionals need to understand the critical issues surrounding the use of biosimilars to make informed treatment decisions.The compl...

Johansen and Sornette proposes that the crash has fundamentally an endogenous origin and exogenous shocks only serve as triggering factors. This endogenous force is shown in price as power law log-periodicity (PLLP) signature prior to a crash. We estimate the highly nonlinear model developed by them using a hybrid approach which combines scatter search, genetic adaptor and tabu search. The mode...

To the Editor: The Department of Surgery at the Nelson R Mandela School of Medicine is proud of its 100% pass rate in the October 2008 Colleges of Medicine of South Africa examinations held in Durban. Most candidates attended the graduation and joined the 3 who passed in May as registered specialists in general surgery. This represents a stalwart effort on the part of the candidates and their t...

ALICEROBBIN ABSTRACT THISARTICLE EXAMINES SELECTED ECONOMIC and social indicators of our multiracial and multiethnic society at the end of the twentieth century to provide an information base for wise decisions about effective library services. The statistical profile describes the demography, economic well-being , and educational attainment of the principal racial and Hispanic origin groups. T...