OBJECTIVE Repetitive umbilical cord occlusions (UCOs) in ovine fetus leading to severe acidemia result in adaptive shut-down of electrocortical activity [electrocorticogram (ECoG)] as well as systemic and brain inflammation. We hypothesized that the fetuses with earlier ECoG shut-down as a neuroprotective mechanism in response to repetitive UCOs will show less brain inflammation and, moreover, ...

PURPOSE Rod photoreceptors are exquisitely sensitive light detectors that function in dim light. The timely inactivation of their light responses is critical for the ability of rods to reliably detect and count photons. A key step in the inactivation of the rod transduction is the phosphorylation of the rod visual pigment, rhodopsin, catalyzed by G-protein-dependent receptor kinase 1 (GRK1). Ab...

Good agreement with field data has been obtained when using a commercial kick simulator to analyse a 56 bbl gas kick taken in a 59 deg deviated wellbore. Fast kick detection and reaction are necessary when drilling at high rates of penetration since high pump rates, necessary for hole cleaning and cuttings transport, imply that a gas influx may be rapidly circulated to surface. A simulated exam...

Like most bacteria, Shigella must maintain a precise balance between the necessity and toxicity of iron; a balance that is achieved, at least in part, by regulating the production of bacterial iron acquisition systems in response to specific environmental signals. Using the Shigella heme utilization (Shu) system, S. dysenteriae is able to acquire iron from heme, a potentially rich source of nut...

Impeller trimming is a proper way to alter the performance of centrifugal pump with a constant speed so as to meet the demand on the specified flow rate and head in pumping systems. The affinity law accounting for the impeller trimming is the key relation to determine the pump performance with a trimmed impeller. There seems no experimental study dealing with such an affinity law for centrifuga...